The Illustrated AlphaFold bit.ly/the-illustrate… Do you want to know how AlphaFold3 works? It has one of the most intimidating transformer-based architectures, so to make it approachable, we made a visual walkthrough inspired by Jay Alammar's Illustrated Transformer! 🧵 (1/7)

I talked about major trends. ◼️One of them is increasing throughput & decreasing cost. Currently, we can analyze over 1,000 proteomes / day. Soon, this will look slow 🚀

A deluge of Thermo patents came in this month: - In-source FAIMS (Thermo version of TIMS, Part A?) - Gradient separation IMS (Thermo version of TIMS, Part B?) - Ardia - Timing Control for mrTOF No signs what the #ASMS2025 instrument will be except for maybe an Exploris

Last week we participated in the science fair at the biocenter of Universität Würzburg #UniWürzburg with a 3d-printed quadrupole ion trap according to a paper from CERN (see scoollab.web.cern.ch/3d-printa). It was fun to assemble and in the end worked out just fine (just the video is slightly shaky)!

By Toby Chambers Christopher Fry Prof Steve Horvath RidgelineTx & Yuan Wen UKY Center for Muscle Biology et al “Methylome–proteome integration after late-life voluntary exercise training reveals regulation and target information for improved skeletal muscle health”Journal of Physiology #myotwitter physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Full Ion Max NG CAD model finished! The internals should be close to 1:1 excluding a few pogo pins and o-rings, the knobs and lock mechanism is fully articulated in fusion 360! Looks real nice in renders too! #teammassspec grabcad.com/library/thermo…

i've had a hard time finding reviews or videos that give a simple high-level overview of how mass spec works! (like, for a new grad student who will be using a mass spec to study cancer but not working on mass spec methods) anyone have a resource they like? (pls RT)

Great thinks about to happen in the Warscheid lab. Building up the tension ...

Some errors you just don't wanna see in the morning.

Very excited that my first paper found its home in Nature Communications, where we show that usnic acid inhibits the nucleolar pre-60S biogenesis in yeast. Here the link to the full publication: nature.com/articles/s4146….

And even a presentation version! Well, except you should read the paper, or at least that "recommendations" paragraph. zenodo.org/records/137605…

Calculating and Reporting Coefficients of Variation for DIA-based Proteomics dlvr.it/TDD6zG Mini write up about CVs with suggestions for technical studies. It highlights some pitfalls and provides an R package to calculate CVs #proteomics #TeamMassSpec

We can predict almost any peptide property: MS/MS retention time detectability But only one paper (that I know) has reported prediction of FAIMS ion mobility (Deng et al An Chem 2022) FAIMS mobility is actually not as simple as you may think... a thread 🧵

Join our Proteomics Facility at U Michigan cores.research.umich.edu/core/proteomic…! We're hiring a Research Lab Specialist Senior. Help us with innovative sample prep, PTMs, low input samples etc. but also regular Core functions. Collaborate with our FragPipe team. Apply: careers.umich.edu/job_detail/254…

I'm always thinking about Lindsay K. Pinos DIA paper in MCP, where they nicely describe the effect of scans across a peak. doi.org/10.1074/mcp.P1…

A bunch of expensive boxes arrived this week. Can't wait to see them run.

Nobel Prize season is a time of amazing science and also often very good science communication. I like the info cards and posters from the Nobel prize social teams.

Ai-ception