Our review on regulation of enhancer "life cycle" in development (activation-silencing-dememorization) is now out in TIBS. Thanks Xiaotong Wu and Xi Wu for putting together this nice article! cell.com/trends/biochem…

🚨One PhD and one Postdoc position opening in my lab! We will investigate how RNA viruses are able to take advantage of host organelles to accomplish their replication and how plants sense and respond to it. 🦠+🌱=⁉️. Operational base = beautiful Potsdam. See call below⬇️

Joint work with @lab_lawson and Yonghao Liang on how transposable elements shape and maintain 3D genome. Thank you Nature Reviews Genetics, and apologize to those whose work we did not have space to cite. @WUSTLdbbs WashU Medicine Genetics McDonnell Genome Institute, WashU Medicine WashU Center of Reg Med nature.com/articles/s4157…

I am happy to share with you the second work of my postdoc @PauliGroup aimed at understanding how maternal mRNAs are stored in the egg : biorxiv.org/content/10.110… Want a summary? Check out our tweetorial here 👇

Check out this brand new work on the role of #H4K16ac in activating transposable elements, and making them function as #enhancers nature.com/articles/s4159… Funded by MRC UK Research and Innovation and Barts Charity 1/3

Well well, what's this?! It's more Z4! Delighted this is now out, big congratulations to our co-submitters Torben Heick Jensen / Jerome Rouviere and the "West Massive" (@XRNchew) , especially my partner in crime Lee Davidson cell.com/molecular-cell…

Our lab is recruiting post docs on the role of nuclear architecture and 3D genome organisation in genome stability. sussex.ac.uk/about/jobs/res… sussex.ac.uk/about/jobs/pos… Be in touch or apply at the links if you are interested! Thanks !!!

It was a long journey from putting together the first observations from many sources to the understanding of #TFIID assembly using co-translation mechanisms published at NatureStructMolBiol in collaboration with the Marc Timmers lab. Thanks for the great help from the IGBMC facilities.

In short, we are looking to hire a number of positions in the next 6-9 months, so if you are interested in these or other interests of the lab, please reach out.

Our new work in ⁦nature⁩ to explain how retrotransposons synthesize the 2nd-strand DNA by a circularization process. Story: made some cool findings (we thought) -> actually scooped 40-yr ago by textbook knowledge -> textbook appear to be incorrect. nature.com/articles/s4158…

Excited to share the final version of my Postdoc work in the StarkLab on mapping and unravelling the regulatory specificities between transcriptional corepressors (CoRs) and active enhancers. (1/5) science.org/doi/10.1126/sc…

Really happy that our paper on Obox, an oocyte/embryo-specific TF family including 8 members and over 60 copies in the genome, as a key regulator of mouse ZGA is now out in Nature! nature.com/articles/s4158…

Are you (or a friend) looking for a molecular biology 🧬🧪 group leader position in a stable, democratic welfare state? 🇩🇰 Then have a look at our call for two faculty (assoc or TT ) 📣 Broad topic, good funding landscape, wonderful colleagues! mbg.au.dk/en/news-and-ev…

The U5 snRNP makes up the “heart” of the human spliceosome, which is made and recycled by two chaperones, CD2BP2 and TSSC4. But how is this done? See our latest work to find out, co-lead by the great Daria Riabov Bassat and Pat Visanpattanasin. nature.com/articles/s4159… (1/5)

I’m beyond excited to present my postdoc work with Plaschka Lab and @JuliusBrennecke at IMP IMBA imbavienna.bsky.social . We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. A thread: 1/x

🎉Congratulations! The European Research Council (ERC) awarded an Advanced Grant to IMP senior group leader Tim Clausen @clausen_lab to study protein misfolding in muscle with the goal to develop new tools against age-related muscle protein disorders. Read more👇 imp.ac.at/news/article/e…

Congratulations to Julius Brennecke for securing one of this year’s European Research Council (ERC) Advanced Grants! Julius will study the arms race between transposons and host genomes. #ERCAdG More here: oeaw.ac.at/imba/research-…

Come and explore the mechanisms of gene expression with us! We are hiring two postdocs in cryo-EM and - with Francisco Balzarotti - in super-resolution microscopy. 👉imp.ac.at/career/open-po… 👉imp.ac.at/career/open-po…

AlphaBridge: tools for the analysis of predicted macromolecular complexes • AlphaBridge introduces tools to analyze and visualize the interfaces between predicted macromolecular complexes using data from AlphaFold3. It processes the predicted interactions into intuitive

Latest from the lab, finally out in Molecular Cell . Here we show a physical and functional link between the Microprocessor and a variant NEXT complex. Together, these complexes degrade the 5' flanks of pre-miRNAs and other stem-loop-containing RNAs. cell.com/molecular-cell…