EVs and mental health disorders: a step towards a better understanding? Our weekly blog explores the potential impact of EV research on the development of diagnostics and therapeutics for major depressive disorder. cellgs.com/.../evs-and-me…...

Genetic modification and expansion of cells for autologous therapy, such as CAR-T cells, is expensive and carries a heavy regulatory burden. High efficiency reprogramming of immune cells with protein has the potential to revolutionize onco-immunology. lnkd.in/edsvsdVr

Why is CAR-T cell therapy so expensive? The cost of many therapies, including CAR-T, excludes widespread adoption. Here, we examine why CAR-T is expensive, strategies to reduce cost, and alternatives being developed. lnkd.in/e-fvfkmb

A better understanding of immune evasion is leading to promising new therapeutic strategies. A recent paper highlights the importance of reactive oxygen species, mitochondria and IL-10 secretion from macrophages in generating immune evasion. lnkd.in/eSCUBPK4

Immune cell boot camps in tumours may explain the abscopal effect Read more in our weekly blog lnkd.in/eM7_ibxd

Better Nerves for regenerative medicine Nerve conduits improve the growth of nerves across injured tissue. Using sustained-release nerve growth factor PODS improves their performance. cellgs.com/blog/sustained…

The central role of TAMs in cancer Tumour-associated macrophages (TAMs) play a key role in the genesis and aetiology of cancer. Unsurprisingly, TAMs are also in the crosshairs of experimental and approved cancer therapies. lnkd.in/e4b6XecK

Parkinson's cell therapy survival agent Recent reports of iPSC-based cell therapy for Parkinson's disease may indicate a therapeutic breakthrough. Second-generation cell therapies may benefit from cell survival agents to support implanted cells. lnkd.in/eahFRXbk

How diet and the gut microbiome influence prostate cancer progression The benefits of a good gut microbiome go beyond the gut and can impact the course of diseases, such as prostate cancer, in other organs. Read more in our weekly blog. lnkd.in/eFzTjSkM

Building better bone marrow models A recent study from Glasgow University describes a bone marrow model that may help to design improved CAR-T cells and guide target selection. Read more in our weekly blog lnkd.in/eFN-b22p

Using Softwell, a recent study has highlighted the importance of matrix elasticity in prostate cancer. Read more in our weekly blog. cellgs.com/blog/hard-luck…

Dependencies can be vulnerabilities. Does cancer's dependency on macrophages create a vulnerability? cellgs.com/blog/macrophag…

Double minutes are tiny chromosome-like structures associated with cancer that can generate uncontrolled increases in oncogene copy numbers. Read more in our weekly blog lnkd.in/eksWyDWe

PROTACs: Degrading can be good Our informative weekly blog explores a technology that is bringing more drug targets into sight lnkd.in/eA8XKAv9

CAR-T in solid cancer? With over 170 companies undertaking almost 2000 projects, CAR-T research is booming. But a myriad of challenges face CAR-Ts in solid cancers. Can they work? Find out more in our weekly blog. lnkd.in/ejj7JCxX #CAR-T

Generating EV microRNA sequence data can be a technically challenging process. However, with the right workflow, backed up by easy-to-use kits from Cell Guidance Systems and Revvity, it becomes routine. Read more at: lnkd.in/e3WXk9b3 #microRNA #extracellularvesicles

🚀 Next-Gen Organoids Meet PODS® Smart Growth Factor Delivery 🧬 ✅ Long-lasting growth factor signalling ✅ Enhanced survival under stress ✅ Stronger expression of stemness markers (Nestin, CD166) ✅ Superior response to injury cues 🔗 lnkd.in/eSyXX9CA

🔬💡There's gold in them there proteins! Can the reductive power of proteins purify gold from waste and seawater? 👉 Read the story here: lnkd.in/eBNn44ue #Biotech #MaterialsScience #PODS #UrbanMining #Nanotechnology #ProteinEngineering #GoldRecovery #CircularEconomy

🚀 A Simpler Way to Model Biological Gradients Modeling gradients in vitro has always been a challenge with complex setups, limited reproducibility, and time-consuming methods. But what if there was an easier way? cellgs.com/blog/an-easier…

🧬 What are SASP “biological-clock” proteins and why do they matter? SASP proteins, which are secreted by senescent cells and act as biological timekeepers within the body. 👉 Read the article lnkd.in/eEb5BryY #BiologicalClock #Senescence #Biomarkers #Longevity