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Come join our team Cell Design Institute @UCSF!

Check out this amazing work from my labmate Matt Kim! He developed a protein degradation system that works in primary T cells to control the activity of chimeric antigen receptors and endogenous proteins! Hana El-Samad Andrew Ng Cell Design Institute @UCSF biorxiv.org/content/10.110…

🚨New Preprint🚨 We developed targeted protein degraders to degrade CARs and endogenous signaling molecules in T cells. The genetically encodable nature of these bioPROTACs enabled us to build a circuit to degrade ZAP70 and inhibit signaling in an antigen-dependent manner.

Exciting new work from Matthew Kim Cell Design Institute @UCSF: Genetically encoded 'bioPROTACs' for antigen-inducible, targeted degradation of key signalling molecules in CAR-T cells. Delighted to be a part of this team! Andrew Ng Hana El-Samad biorxiv.org/content/10.110…

The latest from CDI: Degron-based bioPROTACs for controlling signaling in CAR T cells! Led by Matthew Kim of the Hana El-Samad and Andrew Ng labs! Check it out on bioRxiv. Hana El-Samad Andrew Ng biorxiv.org/content/10.110…

So excited to share our preprint from the El-Samad lab on engineering multiple small molecule and cell contact-inducible systems for controlling gene expression and differentiation in mESCs! biorxiv.org/content/10.110…

So excited to share Sarah Soliman’s new inducible systems for controlling mESC behavior! Sarah built these systems as a stepping stone to studies of tissue organization, but as our neighboring labs began to make use of these tools we knew it was time to share them with the world!

Check out the latest from CDI: "Small molecule and cell contact-inducible systems for controlling expression and differentiation in stem cells" Led by Sarah Soliman Sarah Soliman and Zara Weinberg zara weinberg 🧪🧙🏻‍♀️!!!

Strongly recommend listening to this talk by Wendell Lim - very good overview of how we might engineer immune system 🦠and development 🐣 Generative biology: Learning to program cellular machines. youtu.be/0oG7OMbSWZQ?si…

Dr. Milos Simic DrMilosSimic from Dr. Wendell Lim's lab UC San Francisco discusses harnessing CNS sensors to direct T cells towards brain tumors and other brain disorders. #IOTNCapstoneMeeting

#IOTNCapstoneMeeting: DrMilosSimic UC San Francisco is presenting an approach using central nervous system sensors for targeting T cells to #BrainTumors. #BTAM

Hersh Bhargava Hersh Bhargava from Lim & El-Samad Labs at UC San Francisco presents their work on rewiring IL-2 signaling to better understand and optimize CAR-T cell attacks on immune-excluded tumors. #IOTNCapstoneMeeting

#IOTNCapstoneMeeting: Hersh Bhargava UC San Francisco is presenting that rewiring IL-2 signaling enhances #CARTcell attack of immune-excluded tumors.

I'm so happy to be here in San Francisco, where I'll be working as a Scientist at Cell Design Institute @UCSF! Exciting #SynBio and #CellEngineering ahead!

Welcome to CDI, Alessio Mallozzi!