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Super geeky! A game that lets you break down proteins? The nerdiest game to date! Great idea: Wojciech Pokrzywa Natalia Szulc

Can we conjugate ubiquitin in a non-canonical fashion? Join Breanna Zerfas and me for two compelling seminars at 11 am EDT, 8 am PT, 4 pm BST, 5 pm CEST: @JonathanOstrem: “Direct Small Molecule Ubiquitination” Darci Trader: “Bypassing an E3 Ligase for TPD"

Join our next TPD Webinar, 2nd May, 11AM EDT/ 8AM PT/ 4PM BST / 5PM CEST Stuart Conway, Patrick Brennan - 'Bringing Bump-and-Hole to Molecular Glues: The Development of Orthogonal IMiD-Degron Pairs' Diane Haakonsen - 'Stress Response Silencing in Neurodegenerative Disease'

Join us tomorrow for our next TPD session at 11 AM EST: Sandi Radko-Juettner & Hong Yue “Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF”and Francis Barany “CURE-PROs – Reversible, Self-Assembling Drugs for Targeted Protein Degradation”.

Join us today for a discussion on the newest methods to identify ubiquitinated proteins, discussed by: Hubert Huang, Rosa Barrio, James D. Sutherland, Sagar Bhogaraju, Christian Behrends.

Join us tomorrow for the next #DegradoZoom! We will feature "FBXO22 Molecular Glue" by Elisia Villemure and "Targeting Oncogenic RAS" by Kyle Seamon.

I am looking forward to today's double molecular glue seminar by Michael Erb and Hlib Razumkov. 11 AM EST. …afarbertargetedproteindegradation.org

Endogenous polymerization of BTB domains: Our initial hypothesis was that this would lead to protein degradation, but instead, polymerization led to enhanced chromatin binding at homotypic clusters, causing transcriptional repression. Great story spearheaded by amazing Park Team!

Looking forward to tomorrow polymerization seminar by Jiho Park, Paul Park, Marcin J. Suskiewicz! Join us at 11 am EDT!

Join us for an exciting seminar on Dec 5, 2024, at 12 PM EST: Yifat Merbl (Weizmann Institute): "Proteasome Profiling: MAPPing the degradation landscape in health & disease." Gregory Michaud (Novartis): "Novel Molecular Glue Targets." …afarbertargetedproteindegradation.org

Join us today at 12pm EST for Itay Koren webinar: "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways". …afarbertargetedproteindegradation.org

Join us on April 17th for an exciting double seminar from the University of Dundee Centre for Targeted Protein Degradation: Charlotte Crowe on "Mechanisms of degrader-targeted protein ubiquitinability" and Alessandra Salerno 👩‍🔬 on "FerroTACs." Details: …afarbertargetedproteindegradation.org

Excited to host a TRIM21 double webinar! 🔬 Ting Han (NIBS): Glues & PROTACs for multimeric proteins 🔬 Drew Adams (CWRU): TRIM21 degraders 📅 June 12, 12PM EST 🆓 Open & free Register: …afarbertargetedproteindegradation.org

Join us for the next DFCI #TPD Seminar — July 10, 2025! Chemoproteomic-Enabled Development of Proximity-Inducing Molecules Christopher G. Parker, Scripps Research Details: …afarbertargetedproteindegradation.org Don't miss it!