Here is my biggest contribution to #science so far. A short series of memes inspired by #AlphaFold3 from Google DeepMind 1/9🧵

Extracellular respiration-competent mitochondria float around in our blood ?! 🤯

The Hill-Maini lab website is live Stanford Bioengineering Stanford University. We are hiring for multiple postdocs who are excited about synbio/food/sustainability in filamentous fungi and building an inclusive and lab culture that fosters creativity! Spread the word!!! hillmainilab.com

#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job mpinat.mpg.de/4588467/60-23?…

We have an ERC-funded postdoc position to investigate the fine architecture of #Drosophila nervous tissues by cryo-ET 🪰 Looking for highly motivated candidates with strong background in fly cell biology 🫵 mbexc.de/postdoctoral-s…

How many different things can you grab using a small β-barrel? Sugars, #DNA,#RNA,#tRNA? All of the above. Led by Aline Umuhire Juru, Rodolfo Ghirlando Nature Communications, we find a class of OB-folds in Trbp and Arc1p recognize tRNAs by their universal 3’ ends. go.nature.com/4dj7Bmk

If you want to work in biotech, but don't know what to work on: You should work on plants. Why? A few reasons: Plants account for 80% of all biomass on Earth, there's a low ratio of researchers relative to possible impacts & more. In this thread, I'll try to convince you. 🧵

Deadly kiss of polymerases: How Influenza polymerase cleaves capped nascent RNA from host Pol II to start its own transcription. Preprint from Alexander Rotsch et al. with Steven Cusack‘s lab EMBL Grenoble. biorxiv.org/content/10.110…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

I am excited to join Caltech Chemistry & Chemical Engineering Caltech as an Assistant Professor this November! The Fianu Lab will be a welcoming space for anyone interested in gene activity and genome stability. bit.ly/47gH9I7 We are looking for team members at all levels—please reach out!

Our paper out today @nature: phages reconstitute NAD+ to counter bacterial immunity Phaged invented a new biochemical pathway for NAD+ synthesis - including previously unknown enzymatic reactions - to evade bacterial defenses Congrats Ilya Osterman! nature.com/articles/s4158…

100% that.

Happy to share the latest preprint from our lab led by our very talented postdoc Fernanda Sala! We determined structures of the Nipah Virus RNA polymerase complex in its apo state and with template and product RNA bound during early replication! biorxiv.org/content/10.110…

Nobel prize for AI-based protein structure prediction! Reposting my review on Alphafold2 here: nature.com/articles/s4159…

How To Choose a Good Scientific Problem (1/3)

Many congratulations, Isaac 🎉

PhD Opportunity - I am recruiting a student to investigate mechanisms of co-transcriptional RNA processing in human mitochondria. This is in collaboration with Hauke Hillen and is funded by the DFG DFG public | @[email protected] . Deadline 3 January 2025. Apply below⬇️: bit.ly/3Z2VS5M

The peer-reviewed version of our paper on human tRNA 3' processing is now published in NatureStructMolBiol. Many thanks to the reviewers for their constructive comments! nature.com/articles/s4159… See also the very nice related work by Martin Hällberg Genis Valentin: embopress.org/doi/full/10.10…

Let’s make peer review work for research! Traditional peer review is: 🔸 Opaque 🔸 Uncredited 🔸 Unrewarded 🔸 Slow ✨ Peer review at Research Agora: ✅ Transparent ✅ Recognized ✅ Earn tokens ✅ Fast 💬 How would you like peer review? buff.ly/zbgsxYK

This is exciting! A platform to share small and unpublishable results will be immensely helpful to the scientific community to minimize research waste and address the reproducability crisis. #ResearchAgora #OpenScience