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This is sooo cool!

I was waiting for this paper to come out for a long time! Bravissimo Catarina, Monica and all the rest of the team for this important study!!👏👏👏

Today we report the directed evolution of HUH (a sequence-sequence covalent protein tag for ssDNA labeling) into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA

Biological systems find ingenuous solutions. Almost anything that can happen, happens. Still, I would not have guessed a role of RNA-binding proteins on the cell surface. The Flynn lab are boldly investigating glycoRNAs and following their leads.

Pietro striking again!

one of the most memorable scenes ever! R.I.P. Gene

Protein codes promote selective subcellular compartmentalization | Science science.org/doi/10.1126/sc…

Happy to share this fabulous collaboration with Laurence Lafanechere et al. in which we demonstrate that in addition to synergizing with taxanes, Carba1 remarkably protects neurons from CIPN by stimulating NAD biosynthesis through activation of NAMPT! biorxiv.org/content/10.110…

Genetically encoded reporters of actin filament organization in living cells and tissues: Cell cell.com/cell/fulltext/…

The Allen Cell Structure Segmenter, an #openscience python-based toolkit, help #cellscience researchers navigate complex images of cells by automatically capturing the boundaries of structures. Access at: allencell.org/segmenter.html

✨New paper from my lab out now in Cell ! We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses. cell.com/cell/fulltext/…

Our scientists with over 150 collaborators have released the largest functional map and wiring diagram of the brain to date – seven years in the making. Today’s 1.6 petabyte release marks a historic day for neuroscience. This moonshot milestone will further efforts towards

I am very happy to announce that I will be giving an online talk on #ExpansionMicroscopy at the #ESRIC specialist school 2025 on the 12th of May ! I will present my latest work on iU-ExM and reaching up to 40/50 fold of expansion 🔬 Link here 👉 esric.org/specialistscho…

Great article in Nature about the role of infection in Alzheimer’s disease nature.com/articles/d4158…

Stem cell therapy for Parkinson’s disease has entered a new era. Two nature studies demonstrate that pluripotent stem cell–derived dopamine neurons can survive, restore function, and potentially change the treatment paradigm for this neurodegenerative disease.

🧵 1/8: Excited to share our new paper on how heterochromatin (tightly packed DNA) helps cell nuclei migrate through tight spaces in #Celegans! Published in @genetics_asa #CellBiology #NuclearMigration pubmed.ncbi.nlm.nih.gov/40335054/ Congrats to 1st author Ellen and Dan Starr!

Clearing my postdoctoral opportunities repository- Very useful resource for all #postdocs: List of #funding schemes and opportunities for postdoctoral #fellowships asntech.github.io/postdoc-fundin… by #eLifeAmbassadors Aziz Khan et al. #postdocfunding

We are now accepting nominations. Nominate a deserving early-career investigator today for a chance to compete for a $100,000, 2-year grant! Support the next generation of Alzheimer’s researchers. Nominate ➡️airtable.com/appjJE7FUGZYBU… #CCAD2026 #AlzheimersResearch #EarlyCareer

EndoMAP.v1 charts the structural landscape of human early endosome complexes nature.com/articles/s4158…

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… Jason Buenrostro Fei Chen Lab Ajay Labade Caroline Comenho zack chiang Science Magazine