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Sharing our latest work University of Zurich tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to Andreas Panagopoulos, M. Stout and all co-authors for this tour de force! Beautifully summarized by Sarah Aitken and E. Reilly Nature News & Views nature.com/articles/d4158….

New nature An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer nature.com/articles/s4158…

An ingenious technique reveals how stressed cells divide to produce progeny that have different traits — a phenomenon that can initiate cancer go.nature.com/4jbI7d5

I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in Science Magazine ! (link at end of 🧵)

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

Are you curious about how genomic domains associate with the nucleolus? Check out the latest study from RaffaellaSantoroLab in Molecular Cell. cell.com/molecular-cell…

SUM-seq out Nature Methods! 🚀 Ultra-high-throughput Multiplexed snATAC+RNA Used to: ⏳ link temporal macrophage GRNs to immune disease genetics 🩸 map T cell regulatory landscapes 🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens doi.org/10.1038/s41592… 🧵

Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in Science Magazine! ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells. science.org/doi/10.1126/sc…

Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH

Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu3QxxSyl…

Just out! Aneuploidy alters cellular proteome and affects many functions. One protein, p62/ SQSTM1, becomes highly abundant and creates cytosolic bodies in cells with extra chromosomes. nature.com/articles/s4146…

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1

I am thrilled to share with the world a new preprint, spearheaded by the truly amazing Jose Reyes in partnership with Lowe Lab. Focused on the benign to malignant transition in PDAC, uncovering roles of plasticity, tissue remodeling and P53 -> biorxiv.org/content/10.110…

Today in Cell we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10

Ever wondered why nucleoli often have such complex shapes—despite behaving like liquids? If liquids tend to form spheres, why don’t nucleoli? What shapes them? We explore this in our latest preprint EMBL. Great work led by Daja Schichler & Yuki Hayashi! biorxiv.org/content/10.110…

Excited to share our new preprint on bioRxiv from our great team @EMBL! biorxiv.org/content/10.110… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus

Our latest study is out in Nucleic Acids Research. FEN1 is critical for rapid single-strand break repair in G1 phase academic.oup.com/nar/article/53…

Check out our new paper led by Debasish Paul out now in nature. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is actively inhibiting glycolysis? Cells solve this paradox through a highly dynamic mechanism. nature.com/articles/s4158…

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling Cell Reports. Congratulations to first author Antonio Galarreta and to all co-authors. cell.com/cell-reports/f…. #Microscopy #RNAiScreen #Condensates