Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection pubs.acs.org/doi/10.1021/ac…

The phosphorylation status of Hsp82 regulates mitochondrial homeostasis during glucose sensing in Saccharomyces cerevisiae #Proteostasis sciencedirect.com/science/articl…

The proteomic landscape of genome-wide genetic perturbations cell.com/cell/fulltext/…

IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12 #proteostasis #proteinfolding nature.com/articles/s4155…

Back-to-back JBC papers! Happy to share another JBC paper Journal of Biological Chemistry on the phase separation of bacterial nucleoid-associated proteins. A great collaboration with my departmental colleague, P. Guptasarma Purnananda Guptasarma & his lab GuptasarmaLab_IISERM Dept. of Biological Sciences (DBS), IISER Mohali doi.org/10.1016/j.jbc.…

Chaperone-directed ribosome repair after oxidative damage: Molecular Cell cell.com/molecular-cell…

Check out this week's selection of publications on #MembraneContactSites! biomed.news/bims-mecosi/20… My favourite: doi.org/10.1038/s41556… Thanks to Bims: Biomed News for the pre-selection! #ParkinsonsDisease #Neurodegeneration #MCS #Mitochondria #QualityControl #ESCRT

Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding | bioRxiv biorxiv.org/content/10.110…

Publication alert 🚨In our manuscript, we provide robust methods to biochemically and structurally analyze #mitoribosomes: Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipitation pubmed.ncbi.nlm.nih.gov/37166635/ The Martin Ott lab #Mitochondria

The TIM23 translocase of the inner membrane of mitochondria stabilizes PINK1 and thereby directly influences the distribution of Parkin. Beautiful mechanistic Cell Reports study by Toshihiko Oka and Toshiya Endo relevant for mitophagy and parkinson. cell.com/cell-reports/f…

We're happy to share a new paper (the 1st one!) from our SUMO project. A short summary follows. jbc.org/article/S0021-…

🎉We are thrilled to share our exciting new collaboration with Inada Lab and Jingdong Cheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

We are very proud to share our latest work describing the role of nuclear Hsp104 in protecting the translation machinery during quiescence nature.com/articles/s4146…

We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in Developmental Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-…

I'm so happy that the first paper from my PhD is finally published🙊. We define the tethers in the yeast vacuole-lipid droplets #membranecontactsite and their role in microlipophagy. Major thanks to all the people that contributed to make this story happen 😁

Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with Bukau Lab Vasili Hauryliuk and many others! rdcu.be/dyFTI

Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with Bukau Lab Vasili Hauryliuk and many others! rdcu.be/dyFTI

From MBoC Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding Cells counteract stress by inducing adaptive transcriptional programs. Hsf1 in yeast is solely responsible doi.org/10.1091/mbc.E2…

Latest paper from my former lab- congrats, guys ⁦AndréassonLab ⁩Protein misfolding releases human Heat Shock Factor 1 (HSF1) from HSP70 latency control sciencedirect.com/science/articl…

Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. sciencedirect.com/science/articl…