Cellular migration, cellular mechanical memory, and mechanically-dependent immunesuppression - an inspiring talk by Dr. Konstantinos Konstantopoulos Johns Hopkins University Johns Hopkins ChemBE

Congrats to the Konstantopoulos lab (Konstantopoulos Lab) at Johns Hopkins University on their new Science Advances study! 🎉 They show that extracellular fluid viscosity regulates human #MesenchymalStemCell lineage and function. Read the paper: bit.ly/4h1bdLv

An exciting study from the Konstantopoulos Lab lab reveals that extracellular fluid viscosity alone can drive adipogenic-to-osteogenic stem cell transition, even under adipogenic-favoured conditions. A promising step for the future of #StemCellTherapy ! -YJ science.org/doi/full/10.11…

Check out our latest review where we provide a framework for understanding the interconnected mechanisms of cell mechanotransduction and metabolic adaptation under confinement! doi.org/10.1016/j.ceb.…

Johns Hopkins engineers have discovered how the thickness of fluids surrounding stem cells can affect their behavior and development—insights that have the potential to enhance therapies for bone healing and tissue regeneration. Read more: engineering.jhu.edu/chembe/news/st…

In Science Advances: With NIH support, Johns Hopkins ChemBE doctoral students Alice Amitrano and Qinling Yuan find that viscosity of fluid around stem cells can have a big impact on development, opening up new possibilities for advancing regenerative medicine. engineering.jhu.edu/news/sticky-sc…

Quick trip to DC for the Inquisitive minds retreat! Two days full of discussions on how to treat brain cancer from different angles. Dr. Alfredo Quiñones-Hinojosa Konstantopoulos Lab AliceAmitrano

Putting the brightest inquisitive minds together to find cures for cancer Mayo Clinic Neuro Mayo Clinic Mayo Clinic Comprehensive Cancer Center Johns Hopkins Neurosurgery Johns Hopkins Engineering Johns Hopkins University U Minnesota University of Maryland, Baltimore Konstantopoulos Lab #washDC Paola Suárez Meade, MD Guerrero-Cazares lab Honggang Cui Mayo Clinic Ventures Inspiring

Super excited to share the latest paper from my group published in Science Advances . "Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts" Johns Hopkins BME Johns Hopkins ChemBE The Johns Hopkins Institute for NanoBioTechnology Johns Hopkins Engineering Johns Hopkins University science.org/doi/10.1126/sc…

Excited to share our new publication nature.com/articles/s4146… , showing that viscoelastic matrix enhances cell plasticity and reprogramming efficiency. Congratulations and thanks to Yifan Wu, the team members, and collaborators!

Huge congrats to my first-year PhD student, Josiah Power Josiah Power on receiving an U.S. National Science Foundation GRFP! At just 19 and with a double-major in ChemBE & Biochem, he took 5 doctoral-level courses last fall (vs. the usual 3) and aced them all. Incredible talent and drive- well deserved!

Immense congrats to my amazing postdoc Debanik Choudhury, PhD for winning the Best Poster Award at the 18th Nano-Bio Symposium at The Johns Hopkins Institute for NanoBioTechnology ! In just one year, he’s co-led a COCB article doi.org/10.1016/j.ceb.……, a book chapter , and has several more in the pipeline. Well-deserved!

It was an incredible honor to receive the WSE Doctoral Student Excellence in Leadership Award. I’m grateful for this recognition and proud to be part of such a supportive and inspiring community.

Fresh science! Check out our Confinement Mechanobiology Lab at MBI’s new paper on how confined migration can drive stem cell differentiation in Advanced Portfolio News. Let’s do a thread! advanced.onlinelibrary.wiley.com/doi/full/10.10… (1/n)

Excited to share our work in Nature Methods! InterpolAI is a deep learning framework that uses optical flow to interpolate and restore missing or damaged biomedical images, allowing enhanced 3D maps across diverse imaging modalities. Read more: nature.com/articles/s4159…

Grateful to be part of this impactful work with a fantastic team. Congrats to everyone involved! Don’t miss it ⬇️

Cell migration in confined environments is initiated by a cytoplasmic pool of anillin and Ect2 that promotes RhoA/myosin II-mediated activation at the poles of migrating cells, in a process dependent on the extracellular environment stiffness. nature.com/articles/s4156…

Pleased to share our latest collaborative work with the Devreotes Lab - Johns Hopkins University in PNASNews. Using optogenetics, we show that both insufficient and excessive Ras activity impair cell motility, underscoring the need for optimal Ras signaling and cortical tension. doi.org/10.1073/pnas.2…

Johns Hopkins engineers have discovered two proteins key to cell division also help cancer cells spread, especially through tight spaces. The results have the potential to identify new anti-metastasis drug targets. Learn more: engineering.jhu.edu/chembe/news/jo…