Deciphering how specialized interneuron-specific cell types contribute to circuit function biorxiv.org/cgi/content/sh… #biorxiv_neursci

Excited to share submitted work with Alex Guet-McCreight on virtual inhibitory network modeling biorxiv.org/content/10.110… - made possible by building on collaborative work doi.org/10.3389/fncel.… and doi.org/10.1093/cercor… and more! #KCNhub Krembil Research Institute

#ArticlesinPress - "Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function" Alexandre Guet-McCreight and Frances K Skinner #Dendrites #Ionchannels #Neuroscience University of Toronto ow.ly/CTwP50FPXaO

New neuron modeling study on electrophysiological changes in aging from the lab of Etay Hay and collaborators Shreejoy Tripathy @DrValiante Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity biorxiv.org/content/10.110… #KrembilNeuroinformatics

New work with Kant (Heng Kang) Yao: Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. 🥳doi.org/10.1016/j.celr…

Excited to share this collaborative work, now in its final form: Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity. CAMH Research Krembil Brain Institute #aging doi.org/10.1093/cercor…

I'm really proud to share this data paper on some of our human neuron intrinsic ephys work with @DrValiante, Homeira Moradi, and Derek Howard that is now out at GigaScience! academic.oup.com/gigascience/ar…

My Cerebral Cortex article finally moved from early release to an issue release (doi.org/10.1093/cercor…). Here is some nice cover art by Amanda Sherrington (galleriesherrington.ca) that we had hoped to publish alongside it (not selected, unfortunately).

New CAMH-led research in Communications Biology shows targeting specific brain cells could be a game-changer for treating depression. By simulating pharmacology effects in humans, scientists are getting closer to more effective treatments. ⬇️MORE: doi.org/10.1038/s42003…

EEG biomarkers of GABA α5 positive allosteric modulators in rodents biorxiv.org/cgi/content/sh… #biorxiv_neursci

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory dlvr.it/T5RDx8

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity biorxiv.org/cgi/content/sh… #biorxiv_neursci

Thrilled to share our latest publication on predicting optimal doses of α5-GABAA receptor modulators for depression treatment using EEG biomarkers and computational models. #Neuroscience #Depression #ComputationalBiology #MachineLearning #EEG doi.org/10.1371/journa…

Neuroscience's Grand Question neurosciencenews.com/theoretical-ne… #neuroscience

Giant neuron found wrapped around entire mouse brain like a 'crown of thorns': go.nature.com/2l7Ur1c

UofT CPIN joins us to a packed house for Dr. Eve Marder's keynote talk at #Krembil Research Day