Thanks to Jody Mason and Gregers Rom Andersen for a really interesting viva. Whilst I'm sad that my PhD is finishing, I couldn't have asked for better supervisors in Jean van den Elsen and Alastair Lawson. Such a good experience.

A new research paper in the journal eLife on the inhibition of #complement C5 by peptides derived from cow #antibodies , and the potential use of these #peptides as anti-inflammatory #therapeutics. Congratulations to Jean van den Elsen and his co-authors! complement.org.uk/publications/

An exciting opportunity for a permant position at UCB in Slough. The role involves working within the Immunology TA, to characterise the cellular pharmacology of a novel peptide modality. Check out this job at UCB: linkedin.com/jobs/view/2473…

"Re-mapping of Conformational Distributions Using Small Molecules" featuring an impressive analogy about a canal bridge. frontiersin.org/article/10.338…

Hot off the preprint press: The world's tiniest antibodies can be chemically synthesised!! Alex Macpherson's latest chapter in the continuing knob domain peptide saga: biorxiv.org/content/10.110… #antibody #complement #peptide

We are launching Frontiers E3 Ubiquitin Ligases: From Structure to Physiology to Therapeutics, Volume II frontiersin.org/research-topic… Fumiyo Ikeda @FleurMFerguson Dr Victor Bolanos-Garcia Dr Heike Laman Julien Licchesi #ubiquitin #PROTAC #E3ubiquitinligase. Please RT, thanks.

Latest paper from the lab: providing new insights in the importance of complement in the fluid phase and how C3 fragment dimers modulate B cell activation. Great collaboration between Bath, Newcastle, Colorado and UCB. frontiersin.org/articles/10.33…

The world's tiniest antibodies can be chemically synthesised!! Alex Macpherson et al Laura Kiessling: pubs.acs.org/doi/10.1021/ac…

I'm pleased to announce a PhD opportunity University of Bath to study complement C5, a target for inflammatory diseases, using a unique antibody toolkit. This a collaboration with Prof Paul Morgan, Dr Wiola Zelek Cardiff University and Alex Macpherson UCB News cpb-eu-w2.wpmucdn.com/blogs.bristol.… DM for info

The latest paper from our lab in Frontiers - Immunology unveils a novel staphylococcal #complement evasion mechanism which enables the pathogen to harness the ability of dimeric C3d to modulate B-cell activation via a unique structurally stabilising domain swap. frontiersin.org/articles/10.33…

Delighted that our paper has been published in MAbs. We show that the proximity of the termini of bovine knob domains enables transplantation into protein loops, to engineer binding specificity into proteins and antibodies. The Antibody Society Jean van den Elsen tandfonline.com/doi/full/10.10…

SWBio DTP PhD opportunity ⁦University of Bath⁩ ⁦@BiosciencesBath⁩ in collaboration with ⁦Cardiff University⁩ and ⁦Alex Macpherson⁩ findaphd.com/phds/project/s…

He's only gone and done it!! Congratulations Dr Rhys Dunphy!! Many thanks to the excellent team of examiners Jody Mason and Nic Harmer!! @GW4BioMedDTP @BiosciencesBath

New tool helps scientist understand how MRSA superbug avoids immune detection bath.ac.uk/announcements/… Toska Wonfor, Maisem Laabei, Shuxian Li, Rhys Dunphy, Alex Macpherson @LifeScienceBath University of Bath

DNA is good for information storage. Peptides are better. This Science Magazine article makes a compelling case for peptides encoded small-molecule libraries. A powerful new approach for drug discovery.

PhD position available: unravelling the molecular link between coagulation and immunity. Supervisory team Dr Meike Heurich (Cardiff), Halina Mikolajek (Diamond Light Source) and myself (Bath) gw4biomed.ac.uk/unravelling-th…

As Jean van den Elsen exquisitely summed it up in his historical perspective of the field, "there is complement structural biology before...and after Piet Gros"! What an impactful legacy!