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ACIR

@acir_org

Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in the field. We also make cool cartoons :) Listen to @ImmunoTalks.

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linkhttp://ACIR.org calendar_today14-06-2017 15:30:33

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To support anti-BCMA CAR T cell persistence, Rakhshandehroo et al. generated an antigen- targeted “CAR enhancer” (CAR-E) by fusing BCMA to a low-affinity IL-2 molecule. bit.ly/3XmUThv Dana-Farber   Mohammad Rashidian

To support anti-BCMA CAR T cell persistence, Rakhshandehroo et al. generated an antigen- targeted “CAR enhancer” (CAR-E) by fusing BCMA to a low-affinity IL-2 molecule. bit.ly/3XmUThv <a href="/DanaFarber/">Dana-Farber</a>   <a href="/m_rashidian1/">Mohammad Rashidian</a>
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Focused on reducing severe and dose-limiting toxicities seen with prior IL-2 and IL-12 therapies, Mehta and Rakhra et al. engineered CLN-617, a first-in-class therapeutic for direct intratumoral (i.t.) administration. bit.ly/4cySvIz Cullinan Therapeutics

Focused on reducing severe and dose-limiting toxicities seen with prior IL-2 and IL-12 therapies, Mehta and Rakhra et al. engineered CLN-617, a first-in-class therapeutic for direct intratumoral (i.t.) administration. bit.ly/4cySvIz <a href="/CullinanTx/">Cullinan Therapeutics</a>
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In cocultures of glioblastoma stem cells and in PDX mouse models of glioblastoma, Shanley et al. showed that arming NK cells with IL-21 was safe and induced long-term antitumor activity, while arming [...] bit.ly/4dPYUjQ  Mayra Shanley  Katy Rezvani, M.D., Ph.D

In cocultures of glioblastoma stem cells and in PDX mouse models of glioblastoma, Shanley et al. showed that arming NK cells with IL-21 was safe and induced long-term antitumor activity, while arming [...] bit.ly/4dPYUjQ  <a href="/Mayrashanley/">Mayra Shanley</a>  <a href="/lab_rezvani/">Katy Rezvani, M.D., Ph.D</a>
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Herault et al. demonstrated the efficacy of targeting the costimulatory receptor NKG2D with a bispecific antibody (BsAb) to enhance NK- and CD8+ T cell-mediated antitumor immunity. bit.ly/3AwEv53 Genentech

Herault et al. demonstrated the efficacy of targeting the costimulatory receptor NKG2D with a bispecific antibody (BsAb) to enhance NK- and CD8+ T cell-mediated antitumor immunity. bit.ly/3AwEv53 <a href="/genentech/">Genentech</a>
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Nie et al. showed that thonzonium bromide (TB) occupied the Npl4-binding site on p97 and blocked p97–Npl4 interaction instead of targeting the enzymatic activity of p97. bit.ly/4dqk1cy

Nie et al. showed that thonzonium bromide (TB) occupied the Npl4-binding site on p97 and blocked p97–Npl4 interaction instead of targeting the enzymatic activity of p97. bit.ly/4dqk1cy
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Azar et al. engineered TG6050, an oncolytic vaccinia virus encoding a single-chain human IL-12 p40/p35 fusion and a full-length, ADCC-competent anti-CTLA-4 Ab. bit.ly/3Md6nO0 Transgene

Azar et al. engineered TG6050, an oncolytic vaccinia virus encoding a single-chain human IL-12 p40/p35 fusion and a full-length, ADCC-competent anti-CTLA-4 Ab. bit.ly/3Md6nO0 <a href="/TransgeneSA/">Transgene</a>
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🍦 Still trying to melt the tip of the iceberg: Can IL-2, the first approved immunotherapy, find its use? bit.ly/3X3kv2q

🍦  Still trying to melt the tip of the iceberg: Can IL-2, the first approved immunotherapy, find its use? bit.ly/3X3kv2q
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📦 Getting it where it is needed most: delivering antigen-encoding mRNA directly to DCs ex vivo with LNPs bit.ly/3M6IQOH

📦  Getting it where it is needed most: delivering antigen-encoding mRNA directly to DCs ex vivo with LNPs bit.ly/3M6IQOH
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To target high-risk neuroblastoma, which expresses surface GPC2 (tumor-exclusive, but downregulated under immune pressure) and GD2 (not tumor-exclusive) and is infiltrated by CD16a+ innate immune cells [...] bit.ly/47gwNrG  CHOP Research

To target high-risk neuroblastoma, which expresses surface GPC2 (tumor-exclusive, but downregulated under immune pressure) and GD2 (not tumor-exclusive) and is infiltrated by CD16a+ innate immune cells [...] bit.ly/47gwNrG  <a href="/CHOP_Research/">CHOP Research</a>
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Wang et al. performed paired single-cell RNA and T cell receptor sequencing in 36 patients with stage IV melanoma treated with anti-PD-1, anti-CTLA-4, or combination therapy to study the pharmacodynamic [...] bit.ly/4dQT7uB  Univ. of Pennsylvania Department of Cancer Biology

Wang et al. performed paired single-cell RNA and T cell receptor sequencing in 36 patients with stage IV melanoma treated with anti-PD-1, anti-CTLA-4, or combination therapy to study the pharmacodynamic [...] bit.ly/4dQT7uB  <a href="/Penn_CBIO/">Univ. of Pennsylvania Department of Cancer Biology</a>
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Wakamatsu et al. demonstrated a mechanism of Lag3-mediated cell-extrinsic suppression of T cell activation. Lag3 is a structural homolog of CD4, and following initial TCR–pMHC stimulation, formed clusters with MHC-II molecules [...] bit.ly/3AS6UT4  YOKOSUKA TADASHI

Wakamatsu et al. demonstrated a mechanism of Lag3-mediated cell-extrinsic suppression of T cell activation. Lag3 is a structural homolog of CD4, and following initial TCR–pMHC stimulation, formed clusters with MHC-II molecules [...] bit.ly/3AS6UT4  <a href="/TadashiYokosuka/">YOKOSUKA TADASHI</a>
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Cieri et al. set out to identify immunologically relevant genetic differences (SNPs) between stem cell transplant donors and recipients resulting in minor histocompatibility antigens (mHAgs) of clinical relevance. bit.ly/3Xu6gnz  @danafarber

Cieri et al. set out to identify immunologically relevant genetic differences (SNPs) between stem cell transplant donors and recipients resulting in minor histocompatibility antigens (mHAgs) of clinical relevance. bit.ly/3Xu6gnz  @danafarber
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In melanoma and some other cancers, tumor cell PD-1 expression promotes tumorigenesis, and PD-1 blockade limits tumor growth, even in the absence of T cells. bit.ly/3Xg4CEM  Brigham and Women’s Research

In melanoma and some other cancers, tumor cell PD-1 expression promotes tumorigenesis, and PD-1 blockade limits tumor growth, even in the absence of T cells. bit.ly/3Xg4CEM  <a href="/BrighamResearch/">Brigham and Women’s Research</a>
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To improve anti-PD-1/PD-L1 responses in cancer, Kumar, Tailor, and Dheeraj et al. developed an ex vivo, high-throughput screen to identify drugs that could inhibit macrophage-mediated T cell suppression. bit.ly/3Td88yA  OHSU School of Medicine

To improve anti-PD-1/PD-L1 responses in cancer, Kumar, Tailor, and Dheeraj et al. developed an ex vivo, high-throughput screen to identify drugs that could inhibit macrophage-mediated T cell suppression. bit.ly/3Td88yA  <a href="/OHSUSOM/">OHSU School of Medicine</a>