🚨🚨Randomized Trial Spine SBRT Target Tumor only vs.Tumor+ Elective Coverage 🚨 ↑↑tumor control with Elective Target coverage

🚨 RCT EBRT +/- RFA/PVA for painful spinal mets Pain response at 3 months for EBRT alone vs addition of RFA/PVA: 50.0% vs. 48.3%, p=0.92

❗️ALERT❗️I just got report of Global Sumud Flotilla surrounded by 20 vessels as they reached 70 nautical miles off Gaza coast.

- Abbiamo chiesto agli israeliani di non intercettare la Flotilla in acque internazionali • Ma non è avvenuto in acque internazionali? - Sì • E secondo lei è legale? - No [...] Quello che dice il diritto è importante ma fino a un certo punto Non è AI #portaaporta

Great paper in JAMA Oncology assessing the time period for cure after for colon cancer. It's 6 years. "Cure" is defined as when the risk of recurrence is <0.5%. Very reasonable. jamanetwork.com/journals/jamao…

Radiation Shows Similar 10-Year Outcomes Vs Surgery in Early-Stage NSCLC | CancerNetwork cancernetwork.com/view/radiation…

Protocol Activation! Effective October 07, 2025, NRG-GI012 is open to patient entry. NRG-GI012: Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer with Macrovascular Invasion (HELIO-RT) Mass General Cancer Center conta.cc/4gUhIkD

Here's a question I know many are wondering about: why did China wait until now to use rare earths as leverage against the US? Why not in the first Trump administration when the US started the trade hostilities? Or when the Biden administration unleashed the chips export controls

🧬 PSICHE (NCT05022914): PSMA-PET-guided RT for early BCR post-prostatectomy. After 19 months of median follow-up: ✅ 88.7% ADT-free survival ✅ 81.8% metastasis-free survival EAU Risk group didn’t impact BRFS/MFS. 🔗 doi.org/10.1007/s11547… Vanessa Pietro Garlatti

- Le piazze per Gaza sono antisemite. Figli di papà che se la prendono coi poliziotti che sono pagati quattro soldi - Ma i quattro soldi siete voi a pagarli Lui va in crash #realpolitik

‼️ NorthStar: Metastatic EGFR mutant NSCLC +/- LCT Primary endpoint: PFS mPFS 25.4 m osimertinib+LCT arm vs 17.0 months with osimertinib alone, HR 0.60, 95% CI 0.40–0.92; p=0.02

Il videoblob di tutti gli orrori delle quasi dieci ore di convegno tenutosi al Cnel e organizzato dall’Unione delle Comunità Ebraiche Italiane. Un grazie doveroso a Il Grande Flagello ilfattoquotidiano.it/2025/10/18/7-o…

Il Sole 24 Ore.

RT for massive HCC. In series (n=156) w median tumor size 12.9 cm, local control w RT (+/- opt'l TACE) = 86%. RT dose modest (4Gy x 6-10 fx): HCC is radiosensitive. Recall in RTOG 1112, med size 7.8 cm. IMO among local HCC tx, RT/SBRT has strongest evidence for larger tumors.

Elio Adib Jeff Ryckman I won’t be as charitable - 1)EFS with events including inability to go surgery in a trial with an arm comparing surgery and time starting at randomization? Makes no sense at all.

A press release summarizes what I thought was the most important lung cancer abstract presented at #ASTRO25. It represents the updated REVISED STARS study results from MDACC. astro.org/news-and-publi…

1/ Our Nature paper on radiation-induced AREG sparked discussion - and some misinterpretation (nature.com/articles/s4158…). We clarify key points in our new Authors’ View in the Red Journal (IJROBP - The Red Journal). 🧵 Here’s what we actually found — and what we didn’t: sciencedirect.com/science/articl…

Le immagini che vedete non sono l'irruzione in un pericoloso covo di criminali. La Questura di #Bologna oggi ha deciso che la polizia doveva irrompere armata fino a denti in una casa, sfondando un muro (!) per eseguire uno sfratto. In casa c'erano cinque minori tra cui una

I am genuinely fascinated by the xevinapant (X) story. This drug essentially turns off proteins (IAPs, inhibitor of apoptosis) that themselves turn off apoptosis, hence augmenting apoptosis in cancer cells. Xevinapant functions as a SMAC mimetic, with SMAC an endogenous protein

Great to see the updated BCLC guidelines include RT! RT now incorporated into most major guidelines for HCC (BCLC, AASLD, EASL, NCCN, others) & should be a standard of care option. Full link here: sciencedirect.com/science/articl… OncoAlert