Interesting model from Maya Schuldiner. Yet3 at ER sites recruits proteins in the ergosterol biosynthesis pathway to assemble 'ERGosome', increasing ergosterols for sterol rich contact sites.
On-demand sterol biosynthesis at organelle contact sites biorxiv.org/content/10.110…

Terrific ideas on collagen fibril formation from Karl Kadler. Fascinating roles of secretion and endocytic recycling in fibrillogenesis.
Collagen fibril formation at the plasma membrane occurs independently from collagen secretion biorxiv.org/content/10.110…

#NewPI milestone achieved! Proud to present the first manuscript from our team biorxiv.org/content/10.110…
#ECM #tissuemorphogenesis #zebrafish #devbio

I've reached halfway through a grant application I'm writing. This means it's 50% complete with only 275% remaining.

A breakthrough from the lab! A game-changer and the dawn of a new era in membrane and organelle biophysics and biology. We've generated giant organelle vesicles #GOVs with conserved biochemical activity. ANR Laboratoire de Physique de l'ENS École normale supérieure | PSL Nature Communications
nature.com/articles/s4146…

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🎉 Huge congratulations to my mentor and friend Vivek on his election to the prestigious American Academy of Sciences! His dedication to advancing cell biology motivates us all.

Very nice new work from Vivek Malhotra and Ishier Raote using peptide to target TANGO1 to modulate collagen secretion and scarring.....

nature.com/articles/s4146…

The review we wrote together with Javier Vera Lillo and Julia von Blume @LabVonon on 'Protein #Condensates in the Secretory Pathway' is already online at Biophysical Journal. Check it out if you are interested! 👉
sciencedirect.com/science/articl…

🗣️If you are interested in #organelle_signaling 🤩, join us on june 20st in #Rennes Université de Rennes, it is free (just DM me to ensure we still have seats), ligth logistics, great lineup of speakers !!! and wheather should be enjoyable (can't promise) ☀️ Oncogenesis_Stress_Signaling Inserm Grand Ouest

#membrane seminars are back THIS THURSDAY! Great lineup with Stephen Royle @[email protected] and Ewan MacDonald!

In their Cell Science at a Glance article and poster, Stéphane Vassilopoulos Steph Vassilopoulos Inserm @Sorbonne_Univ_and Guillaume Montagnac review our current knowledge of membrane-associated clathrin assemblies.
journals.biologists.com/jcs/article/13…

Is N-glycosylation really non-regulated, constitutive? Rohatgi lab shows control of OST-A at specific sequons on specific protein.
Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface biorxiv.org/content/10.110…

En route to Barcelona for a meeting with collaborators and brainstorming session on therapeutic strategies to deal with fibrosis.
Looking forward to pleasant, uninterrupted hours in the train to catch up on papers, paper reviewing and a miserably stalled grant application.

✍️The Raote Lab (Ishier Raote) published a new article in Nature Communications 'TANGO1 inhibitors reduce collagen secretion and limit tissue scarring'

➡️urlz.fr/qqLn

A masterful X-plainer (😆) from Ishier Raote, showing us how it should be done! Really exciting work and an artfully organised collaboratory project.

📢 P L E A S E spread the word‼️ Registration is open for The International Plant Proteostasis Conference, in VIENNA, 17-20 September, 2024: oeaw.ac.at/gmi/news-event… Great line up, exciting topics, and friendly meeting. Please register early. #ippc24

👀This is a fascinating paper about the role of TANGO1 💃🕺 in #collagen secretion. Huge kudos to everyone who contributed to the paper, and for this awesome tweetorial!

Beautiful images from Bewersdorf Lab. 'Rapid multiplexed super-resolution microscopy that can, in principle, be applied to a nearly unlimited number of molecular targets': FLASH-PAINT at 3D super-resolution.
cell.com/cell/fulltext/…

Interesting from Ray lab TIFR India: insulin signaling regulates directionality and flux of axonal Rab4 vesicle traffic
Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98a/KIF16B recruitment via Vps34-PI3Kinase biorxiv.org/content/10.110…