【研究成果発表】 「長鎖シーケンスによるヒト免疫細胞のRNAデータベースの構築」（難治疾患研究所 教授 高地 雄太、非常勤講師 稲毛 純） プレスリリース tmd.ac.jp/press-release/… DOI: doi.org/10.1038/s41467… #東京医科歯科大学 #tmdu

A new paper by Jun Inamo, Yuta Kochi et al: “I Long-read Sequencing for 29 Immune Cell Subsets Reveals Disease-linked Isoforms” in Nature Communications. DOI: doi.org/10.1038/s41467… #東京医科歯科大学 #tmdu Nature Communications

CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial Nature Medicine nature.com/articles/s4159…

CXCL13 shows up prominently in T cells in autoimmune tissues and tumors. Human Tfh and Tph cells produce lots of CXCL13, yet its regulation is pretty unclear. With beautiful CRISPR screens by Jaehyuk Choi, Calvin Law, we found a few key factors... nature.com/articles/s4158…

In a new work led by Rebekah Loving, joint with Ali Mortazavi and his lab, we introduce a method based on kallisto for accurate quantification of Oxford Nanopore or PacBio long-read RNA-seq, and demonstrate its accuracy with numerous comparisons and benchmarks 1/🧵 biorxiv.org/content/10.110…

Introducing The AI Scientist: The world’s first AI system for automating scientific research and open-ended discovery! sakana.ai/ai-scientist/ From ideation, writing code, running experiments and summarizing results, to writing entire papers and conducting peer-review, The AI

Paper list of longitudinal single cell neurobiology studies (scRNAseq/scATACseq/spatial transcriptomics) 🧵🧠: 1. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution | Cell 2022 | Ryan Lister Lab, The University of Western

"Alignment of Read1 cDNA segment (position 59-150) is reliable with Element but not Illumina sequencing." cool study from Aaron R. Quinlan Lab Aaron Quinlan. I also recently analyzed some snATAC-seq data (libraries constructed using 10x Genomics kits) sequenced by Element Aviti

Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response dlvr.it/TDJCDJ

Thrilled to share new collaborative paper from my former lab using long-read sequencing technologies! Congrats, Mahoko-Sensei!

Excited that I am going to give 2 oral talks for multi-modal single-cell study at #ACR2024 ! 1. "RA – Diagnosis, Manifestations, & Outcomes II: Bad Blood" session | with CU Anschutz Division of Rheumatology 2. "Sjögren's Syndrome – Basic & Clinical Science" session | with Keio Global

Today I’m gonna talk about single cell study for At-Risk RA! #ACR24 #ACR2024

Come to hear our exciting work of 👏deciphering activated lymphocytes using deep immunophenotyping, both #singlecell CITE-seq and CyTOF, for at-risk #RheumatoidArthritis with cross-cohort validation #ACR24 American College of Rheumatology

Great talks already from Judith James and Joel Guthridge. Looking forward to hearing from Jun Inamo, M.D., Ph.D., Roopa Madhu, Dr. Fan Zhang ⛵️, and Kevin Bu. #ACR24

Today I’m going to talk about single-cell study which reveals heterogeneous T cell populations and activated fibroblasts in salivary glands of Sjögren syndrome/disease! Keio Global #ACR24 #ACR2024

The GTEx V10 has been released. Compared to release V8, V10 has 12% more RNA-seq samples and 23% more samples used for eQTL analyses. V10 release includes new smallRNA-seq data from 16,760 tissue samples, including gene expression counts and cis-QTLs. It also includes deep