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💡 Researchers provided insights into the critical role of #mitochondrial 1-carbon metabolism and MTHFD2 in governing the differentiation of CD34-lineage cells into Tfh cells. Circulation | bit.ly/4et8sCW

📊 Researchers at Univ. of Maryland found that CD8+ T cells promote homing of CD4+Foxp3+ T regulatory cells to the tumor bed by increasing levels of CCR5 chemokines in the tumor microenvironment in an IFN-γ and TNF-α dependent manner. 🔗 bit.ly/4lxrlqF

💉 Investigators described an association between mechanosensation and cross-presentation by cDC2A cells, contributing to the continued development of dendritic cell vaccines. 🔓 Journal for ImmunoTherapy of Cancer | bit.ly/45DyeBW

💡 Although LAG-3 is known to bind to major histocompatibility complex class II, Dr. Jasper Du and scientists at NYU Grossman School of Medicine demonstrate that MHC class II interaction alone is insufficient for optimal LAG-3 function. Cell | bit.ly/45SIl66

🧪 Dr. Giulia Marelli and researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages, confirming the function of known regulators in TAM responses and revealing new insights into the behavior of these cells. 📖 Nature Immunology | go.nature.com/4kkKVFg

🔎 Scientists at BIDMC investigated how CD39-AS affects the function of #Tregs and Th17 cells in healthy subjects and inflammatory bowel disease patients. 🔗 go.nature.com/3HeW3WD

New in Nature Immunology! The Russell Jones at the Van Andel Institute (VAI) identified the prostaglandin I2 (prostacyclin) receptor PTGIR as a cell-intrinsic regulator of #Tcell exhaustion. go.nature.com/4lcyE7i

📢 valentinavenzin, Cristian Beccaria, and a team in the Iannacone Lab showed that CD4⁺ T cells can license #Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. go.nature.com/3Ggjajr

Register now for On Demand Access to Keystone Symposia #NeuroImmune Interactions : A Systems Wide Perspective, this June to explore emerging research! hubs.la/Q02-rZFh0 #KSNeuroImmune25

New in Genome Biology! A team at Sun Yat-sen University performed a meta-#GWAS and identified susceptibility genes for nasopharyngeal #carcinoma. bit.ly/4lmnE7e

⌛ Tick tock, one week on the clock! Subscribe to one of our 20 immunology or cell biology newsletters before July 18 for a chance to win a personalized lab coat. bit.ly/3YYyzuM

Drs. Daolin Tang, Ruochan Chen, and co-authors explore the therapeutic potential of targeting pattern recognition receptors in treating infectious, inflammatory, #autoimmune, and malignant diseases. | Signal Transduction and Targeted Therapy(STTT) 📚 Read the review: go.nature.com/46JeAVs

💡 Jing Xuan Lim and researchers at Newcastle University demonstrate that PD-1 deficiency enhances the function of #Treg cells through expression of a compensatory network of coinhibitory receptors. 🔓 Nature Immunology | go.nature.com/4kNYNbB

💓 Dr. Ying-Jie Wang and scientists at University of Oxford reported that postmortem and explanted human hypertrophic #cardiomyopathy hearts exhibited chronic focal leukocyte infiltration and prominent activation of immune cells. Science Translational Medicine | bit.ly/40X2ynP

🐁 Scientists at Tongji University showed that mice with systemic, Kupffer cell–specific, or myeloid cell–specific Mas1 deficiency were vulnerable to liver ischemia-reperfusion injury. 👉 Science Translational Medicine | bit.ly/4m3KPDu

🎯 Drs. Xian Li, Wenhao Chen, and Dawei Zou at Houston Methodist show that targeting stem-like CD4+ T cells offers great therapeutic potential: disrupting their persistence could mitigate #autoimmune pathology and transplant rejection! 🔗 go.nature.com/4kU4PYj

💩 Researchers showed that a new strain of the bacterial genus Hominenteromicrobium isolated from the feces of patients who responded to programmed cell death 1 blockade augmented #antitumour responses in mice. nature | go.nature.com/46oJCSG

🦴 Researchers with Hua Jiang at Medical University of South Carolina (MUSC) show that ST2+ Treg cells are enriched in bone marrow of humans and mice with AML and promote CD8+ T cells depletion and exhaustion. 🔓 Nature Communications | go.nature.com/46UUAiP

🧫 Researchers engineered a bispecific #antibody, FRP303, targeting 4-1BB and CCR8, which are co-expressed on a highly immunosuppressive subset of tumor-infiltrating regulatory T cells. 👉 iScience journal | bit.ly/4lNUmyI

🩺 This review analyzes recent findings regarding the role of #Treg cells in colon cancer progression by evaluating preclinical and clinical studies that explore immune cell composition, function, and modulation within the tumor microenvironment. 👓 bit.ly/4m9Z1L3