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We cracked the tRNA specificity of FaRel2 toxSAS. A fun collaboration with the Suzuki Lab., Garcia-Pino Gemma C Atkinson and Polikanov. Out in Science Advances! science.org/doi/10.1126/sc…

It has been a journey and here it is: my first post doc paper is out in Nature Communications 🎉🎉🎉 If you red the preprint, it's worth checking the revised manuscript, we added some cool stuff. A thread. ⬇️ nature.com/articles/s4146…

Thanks to Arturo Carabias & Guillermo Montoya (Guillermo Montoya) for the beautiful review of our discovery and especially for the very nice and clear summary figure - I will use it a lot😀

Thank you to Lundbeckfonden, Novo Nordisk Foundation & European Research Council (ERC) for the support!

Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with Siân Owen, Michael Baym, Natalia Quinones-Olvera, Kesther and Carmen! biorxiv.org/content/10.110… 1/

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/sc… The work was supported by IGBMC, Inserm, CNRS 🌍, -, @ERC_research, IMCBio Graduate School, and Instruct-ERIC. 1/7

Very happy our paper on Zorya anti-phage defense system is now published in nature! 🥳 Big congrats to first authors haidai HU and Philipp Popp and all other authors! Wonderful collab with Marc Erhardt and SimonJackson #cryoEM CPRatUCPH Københavns Uni nature.com/articles/s4158…

Excited to share our latest collab with Wenyuan Han's Lab! 🚨 Bacteria use dITP as an immune signal to activate NAD+-depleting effectors. Phages counter immunity by destroying dAMP (dITP precursor)! 💥🧬 Preprint 🔗: biorxiv.org/content/10.110…

1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski Lab Typas Lab EMBL, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! biorxiv.org/content/10.110…

Thank you to Nathan P. Bullen and Aaron Whiteley for the beautiful review of our NARPs paper.

Very happy to share our new review in Molecular Cell covering nucleic acid recognition and effector mechanisms for various prokaryotic immune systems! Was a great experience creating this with @MarraffiniLab! cell.com/molecular-cell…

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

Our paper out Cell: Structure-guided discovery of viral proteins that inhibit host immunity Congrats Erez Tzvi Yirmiya, Azita Leavitt, Gil Amitai 🎗️ 🇮🇱🎗️, our collaborators @ Kranzusch lab, and coauthors A 🧵 1/10 cell.com/cell/abstract/…

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in nature 🥳 Thanks to all the people involved especially the Kranzusch lab and Sorek Lab nature.com/articles/s4158…

Our paper out nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats Tanita Wein! Thanks Kranzusch lab! tinyurl.com/CA88DD

Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)

And here it is, the completed BASEL collection finally published as early access in PLOS Biology - see the thread for more details. 🤗🧬🎣

CRISPR continues to amaze me! Excited to share the last project from my PhD, co-led by the incredible Puja Majumder and myself! We studied the CRISPR effector Cat1, which forms beautiful filament networks to degrade NAD+. Out today in Science Magazine! science.org/doi/10.1126/sc…

📢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

📢 Preprint out! Together with Renee Chang and the amazing Sorek Lab , we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris! biorxiv.org/content/10.110…