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Antibiotics shift the microbiome, cause gut dysbiosis, and can compromise the treatment of cancer using immunotherapy. Fecal transplant (FMR) can help and may improve survival Dr. Lisa Derosa #mascc25 MASCC

Patients with metastatic breast cancer thought to have the HER2 negative subtype may actually be HER2 low or ultra low and may benefit from targeted therapy. Dr. Niharika Dixit #mascc25 MASCC

It's much easier to PREVENT nausea than to treat it and play catch up during the treatment of cancer Maryam Lustberg MD, MPH, FASCO #mascc25 MASCC

Symptom management is ESPECIALLY important for patients with METASTATIC disease because they want to focus on QUALITY of life. Also starting supportive care with the HIGHEST dose to allow tolerability of treatment Eva Schumacher-Wulf #mascc25 MASCC

"*I* am not triple negative, my CANCER is triple negative and I am TRIPLE POSITIVE!" -Eva Schumacher-Wulf, patient advocate Great outlook and attitude ♥️👍 Eva Schumacher-Wulf #MASCC25 MASCC

Dr. Maria Kouri explains how pain is a sensory AND emotional AND social experience. The ORAL microbiome can modulate pain-related signaling in the mouth (eg mucositis) #mascc25 MASCC

Dr. Suzann Duan explains how the ENTERIC nervous system (ENS) helps our gut work, and how cancer chemo kills nerves in the ENS, leading to an array of issues that differ by chemo type. #mascc25 MASCC

Dr. Manuel Morales explains his study of human samples showing that the total number of neurons and glial cells decreased in patients who received oxaliplatin chemotherapy. pubmed.ncbi.nlm.nih.gov/39335466/ #mascc25 MASCC

Nienke Zwart discussed B vitamins (B2, B6, B12, folate) in a metabolic pathway targeted by 5FU and capecitabine chemo to treat colorectal cancer. B vitamin levels MAY be related to chemotixicities. Eg supplemental folate can interfere w prescribed DOSING of chemo. #mascc25

Dr. Kok showed that higher fiber intake was associated with less diarrhea but more flatulence in patients with colorectal cancer. Reduced diarrhea was associated with BETTER quality of life. #mascc25 MASCC

Dr. Kord M. Kober discussed how patients with cancer have different experiences of fatigue (morning vs evening), and found perturbed DNA methylation and RNA expression in several inflammatory pathways. #mascc25 MASCC

Dr. Daniel Hertz: even though patients get a atamdard dose of chemo (eg 80 mg/m²), some pts have higher systemic exposure to that chemo (eg due to metabolism), leading to worse neuropathy. Also vitamin D insufficiency increases risk for neuropathy #MASCC25 MASCC

Dan Hertz: taxane chemo induced #neuropathy is NOT WELL PREDICTED by genetic factors. If they were there, we would have found them by now, and if they ARE there they are likely small in magnitude. Time to focus efforts on neuropathy in other areas! #MASCC25 MASCC

Marialuisa Vigano's work suggests that CBD may improve chemo induced neuropathy for some, and WHO responded may be predicted by greater biodiversity in the gut microbiome. Still exploratory #mascc25 MASCC

Huah Shin Ng shared data from patients with cancer who are in MANY drugs at once (polypharmacy) #mascc25 MASCC

Mangyeong Lee used Chat GPT-4o to assess symptoms from phone logs with patients with cancer. Looks like GPT has a way to go before it works as well as a person #mascc25 MASCC

Former Maryland Governor Governor Larry Hogan celebrating the great Dr. Kevin Cullen and cancer research and care at University of Maryland, Baltimore : Cancer doesn't care if you're white or black, rich or poor, it affects us all.

Without clinical trials we wouldn't have the available treatments we have today youtube.com/watch?v=kCy3gR…