🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🚨 Our new #preprint is out! doi.org/10.1101/2025.0… We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)

📢 MorphLink is out now in Nature Communications! A framework designed to systematically identify disease-related morphological–molecular interplays. Congrats to Jian Hu Emory University and the team MD Anderson Cancer Center. nature.com/articles/s4146…

Our latest work in Nature Communications! 🎇 MorphLink identifies and visualizes disease-relevant molecular–morphology interplay. Congrats to Jing Huang at Emory Genetics, and many thanks to Linghua Wang, MD, PhD’s team at MD Anderson for the great collaboration! 🔗 nature.com/articles/s4146…

📢 Now live at ⁦nature⁩ Our team discovered that PPP2R1A mutations are linked to improved response to immunotherapy in ovarian clear cell carcinoma. ⁦Yibo⁩ ⁦Amir Jazaeri⁩ ⁦Rugang Zhang Lab⁩ ⁦⁦MD Anderson Cancer Center⁩ nature.com/articles/s4158…

Our study on the role of PPP2R1A mutations in cancer immunotherapy is online now! Thanks so much to the guidance and support from my wonderful mentors Linghua Wang, MD, PhD Amir Jazaeri , our fantastic collaborator Rugang Zhang Lab , and all the patients and their families!

DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with Wanding Zhou lab. Kudos to Chin Nien Lee Chin Nien Lee and Hongxiang Fu! biorxiv.org/content/10.110…

Thrilled to see our work led by yunhe liu published in Cancer Cell featured by Nature Custom Media nature nature.com/articles/d4247… Huge thanks to Ian Le Guillou for the thoughtful interview, beautifully written piece Aubrey Bloom Clayton Boldt, Ph.D. MD Anderson Cancer Center for their support

Pathology-oriented multiplexing enables integrative disease mapping nature.com/articles/s4158… PathoPlex is a highly multiplexed imaging at subcellular resolution with a software package (spatiomic) to interpret protein co-expression patterns (clusters) across biological layers.

Anirban, we’ll all miss you so much! I’m so glad our collaboration will continue as you begin this exciting new chapter at NYU. Wishing you all the very best!

📜New in Science Magazine: not one but two papers from team MATCHMAKERS! The labs of David Baker Institute for Protein Design and Chris Garcia StanfordEM published work that could revolutionise immunotherapy. The Baker lab unveil a generative AI pipeline to design precise binders for

Towards Robust Foundation Models for Digital Pathology 1. This study investigates the robustness of biomedical foundation models (FMs) in digital pathology, revealing that current models are highly susceptible to non-biological technical variations such as staining differences

Nature research paper: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity go.nature.com/4lOZKSc

A plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues Cell Paul Macklin Genevieve Stein-O'Brien cell.com/cell/fulltext/…