Great guest lecture yesterday by John Ingraham on Generative Models for Science youtu.be/4dyf_SALtxM

This week in nature, Olga Dudchenko 🇺🇦 and thednazoo team join with @R_Mallarino and Jorge Moreno 🪼 to study the evolution of gliding in marsupials. Beautiful example of how rapid genome assembly enables new model organisms (here, sugar glider) for a specific problem.

What limits rubisco function? Is it the chemical mechanism? Evolution? In an updated pre-print Michael Prywes et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)

V happy to see this out - reprocessing 5million SARS-CoV-2 genomes to remove systematic errors (+thereby improve the phylogeny) and improve representation of genomes from the Global South. Huge amount of work esp. from Martin Hunt, Angie Hinrich+collabs biorxiv.org/content/10.110…

Our recent preprint arxiv.org/abs/2403.03154 — truly at the intersection of AI & physics — evaluates the ability of LLMs to perform advanced theoretical physics calculations.

If you haven't refreshed your view of ONT with recent data you are miscalibrated: "A few years ago, a good ONT-only bacterial genome assembly would contain hundreds to thousands of errors" - "ONT-only bacterial genome assemblies now regularly have <10 errors"

DZD has two talks and a poster this year at ASM! If you're interested in genomic ML for antibiotic resistance prediction come drop by

Honored to be featured in a press release by #ASMMicrobe. Great presentation by Jason Wittenbach. AI Enables Faster, More Effective Antibiotic Treatment of Sepsis | ASM.org

A very cool story from our colleague Stefan Pulst University of Utah! nature.com/articles/s4158…

Check out our latest work! 👇We leverage pretrained protein generative models (here Chroma Generate:Biomedicines ) as a prior for inverse problems in protein space (e.g. structure completion, distance contraints, cryo-EM model building). ❄️🏗️ Paper: arxiv.org/abs/2406.04239

It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago. 🦣💨 Don’t miss our thread below! 🧵👇🏽

How do you redefine what's possible in science? Ask John Ingraham, our Head of Machine Learning, who was named to Boston Business Journal's 2024 40 Under 40! John’s a pioneer in Generative Biology, using ML and AI to revolutionize drug discovery. Congrats, John! lnkd.in/eKaA94-F

AI-Science: New features! - Human-AI copilot app: Much more powerful (and fun) than the AI agents doing it all. - Fully annotated figures! - “Data Chaining”: All results (inc Figures) are click-traced to the specific code lines that created them! pip install data-to-paper

A few years ago there was a lot of activity around photonics-based DL accelerators. Bunch of very well-capitalized startups, lots of research, although iirc, the chips were mostly suited for "inference." Does anyone know if any of that has started to show promise?

Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ Jennifer Garrison Tammy Lan David Fischer AlisonKochersberger Ruth Raichur Sophia Szady

🔎 Asking for a friend (really): What are the best health-tech/diagnostics incubators out there? US-focussed but world-wide is okay, too. First-time entrepreneur with lots of Pharma experience is looking to get started building and wants to do so in that kind of environment.

Congrats Noam Prywes and team! Carbon fixation is next to godliness

Announcing Encode: AI for Science We're launching a fellowship powered by ARIA to connect top AI talent with leading UK science labs to unlock the next wave of scientific breakthroughs.

I don't think the richest person in the world should be holding back funding for cancer research in violation of both the law and court orders

It's been an amazing 9-year journey building DZD, and I could not be more proud of the groundbreaking technology we’ve created. I’m excited to see what we can accomplish as our team transitions to bioMérieux to integrate our work and accelerate our shared mission.