Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model. | Mitsunobu R. Kano 岡山大学 | [50 days' free access] #3Dmodel #TumorMicroenvironment #permeability authors.elsevier.com/a/1iqtTcI2-5wYT

Beautiful figures, looks like a must read for anyone interested in anything fibro.

[PRESS RELEASE] Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model t.u-tokyo.ac.jp/en/press/pr202…

A new paper has been released. Authors: Hiroyoshi Y. Tanaka et al. Title: Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model sciencedirect.com/science/articl…

1. My top imaging trick to trainees is that before they spend any time taking pictures of the data they just sit there for a while & look at the stuff. Like seriously, sit back, crank some tunes, get cozy & spend some quality time with your slides.

The MemBright PM stains set a high bar for specific membrane labeling. But if you care about the phototoxicity under time-lapse and SR imaging? Here we present a gentler palette -- PK Mem dyes. Tailored for live cell SIM/STED! biorxiv.org/content/10.110…

I wish there were more hybrid conferences, i.e. an option to listen and watch remotely. Not everyone can travel. #AcademicTwitter

Do cancer cells 1) survive despite a hypoxic microenvironment or 2) thrive because of a hypoxic microenvironment? If 3) it depends, what are the critical determinants?🤔

Finalizing my poster for #WSPH2024. I will be presenting our findings on PDGF signaling in #PulmonaryHypertension (Abstract A52) on June 29th, in BASIC SCIENCE-2. PATHOBIOLOGY AND MECHANISMS OF DISEASE. Looking forward to meeting new people and ideas!

33 hours of travelling, and I'm finally here. Checked in, put up my poster, and I'm excited for tomorrow! #WSPH2024

Obligatory shot in Barcelona. Still #Unfinished, and herein lies the similarity with my research projects.

Beautiful weather, beautiful venue, engaging talks. 2nd day of #wsph2024

Taking a stroll around the beautiful city of Barcelona after #wsph2024. Learned a lot, met new people, discussed ideas, and scheduled further discussions. Overall, very satisfied.

Time to say goodbye to the beautiful city of Barcelona and head home. Twas nice coming back after my visit in 2013: beautiful views, kind people, nice food (always a plus) and the energy and diversity ever present. I hope to come again! (Btw, that's a statue of Columbus.)

What is the #fluorescent probe of choice for detection of #hypoxia in #3DCellCulture? Compatibility with fixation (4% PFA) would be preferred, but not strictly mandatory.

Attended the 40th Annual Meeting of the Japan Society of Drug Delivery System in Tsukuba. Gave two talks and received nice feedback, chatted w/collaborators and friends, and met new people. Heading home to rest🥱.

More or less accurate for most professions.

The amount of money journals are charging researchers to get their paper to be open-access is egregious science.org/content/articl… Science Magazine by Jeffrey Brainard

Maybe a silly Q: are cells able to sense #collagen fiber thickness? We know collagen fiber thickness is altered in various disease states, but apart from its effect on the mechanical characteristics of the tissue, can cells discriminate between thin vs. thick fibrils? If so, how?