Learned something new from Joe Norman' talk at #RWRI today -- Turing patterns can form in an *extremely simple* discrete cell automata: Here's my code using Young's model (1984) created in HAL): github.com/JeffreyWest/HA… (the C.A. rules are in the next tweet)

Pleased to announce the release of #AndersonLab latest tool: GATTACA, for base pair resolution mutation tracking in agent-based models like HAL. Developed by Ryan O Schenck for our somatic evolution studies. Here’s a cool gif! biorxiv.org/content/10.110…

#HAL showcased on Hungarian national tv! Thanks Gergely Röst for using our hybrid automata platform!

Check out the landing page for Communications Medicine nature.com/commsmed/ highlighting Maximilian Strobl latest paper nature.com/articles/s4385… we see a gorgeous multi panel set of simulations using HAL

Another neat example of modeling using HAL , this time in SARS-CoV-2 applications: mdpi.com/1999-4915/14/5… nice work Gergely Röst & Sadegh Marzban et al 💯

Pleased to share a new collaboration with Carlo Maley on Centre for Evolutionary Therapy led by Daniel Thomas: In Silico Investigations of Multi-Drug Adaptive Therapy Protocols mdpi.com/1655416 Another great application of HAL!

My latest weekend project: implementing Bert Chan's Lenia project in HAL. It's an elegant and mathematically beautiful method to extend discrete cellular automata (e.g. Game of Life) to allow continuous states. 🧵 incoming thread of cool automata gifs:

Please to announce our latest paper led by Ryan O Schenck just out in PNASNews on how, Homeostasis limits keratinocyte evolution. #AndersonLab Many years in the making with help from Eunjung Kim, Rafael Bravo, Jeffrey West Simon Leedham & Darryl Shibata pnas.org/doi/10.1073/pn…

I’m excited to share our recently published manuscript in PNAS on clonal dynamics in the homeostatic epidermis. This paper took a winding course and was the first project that was incorporated into my DPhil. 1/🧵

Moffitt Researchers Use Computer Modeling to Understand How Self-Renewal Processes Impact Skin Cell Evolution #AndersonLab IMO Moffitt Cancer Center moffitt.org/newsroom/press…

This is so cool, our theoretical work led by Jeffrey West with Mark R-T using HAL comes to similar conclusions but we use a buffer agent to modulate acidity and our model is of a more generic ductal tumour: biorxiv.org/content/10.110…

Re-sharing this old blog post on combining HAL with #EvoFreq: mathematical-oncology.org/blog/evofreq-a… even though i wrote it, i still refer to it myself when building models 😅

Super chuffed to see Jeffrey West artwork generated with HAL on the cover of Trends Cell Biology for our recent article with Mark R-T on how, Agent-based methods facilitate integrative science in cancer. cell.com/trends/cell-bi…

"Spatial interactions modulate tumor growth and immune infiltration" Our latest preprint: Sadegh Marzban in collab w/ Amelio Lab! We apply methods from artificial life, Bert Chan's #Lenia, as a model of tumor-immune: - spatial growth dynamics - cell-cell competition & - cell

A thread on our #metaphenotypes paper: frontiersin.org/journals/immun… 🧵🧵🧵

Immune escape is a logical setting to implement an investigation into collective/group phenotypes (e.g. metaphenotypes, if you will) Tumor-immune interactions are by a definition, a collective phenomenon by requiring the presence of two cell types interacting in close proximity:

It's so cool to use HAL to run the same simulation, but color-code and visualize many different ways:

Exciting News! Lenia-in-HAL! 🚨 We released Lenia in the Hybrid Automata Library (HAL) and everyone can implement Lenia using this link github.com/MathOnco/Lenia…