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#teamtomo #EMBOCryoEM We are very proud of this bunch! #subtomosunday

Had an amazing time at the #EMBOCryoEM course EMBL in Heidelberg. Sad to leave and looking forward to keeping in touch with this awesome group of people.

Glad to share our new paper on exploring the limits of cryo-ET. We elucidate how the translation machinery in a simple bacterial cell work, from the near-atomic detail to a whole landscape picture. And what happen when perturbed by antibiotics. check out nature.com/articles/s4158…

Are you interested in inflammasomes and biochemistry? Then this one might be for you: we investigated the common NLRP1 variant M1184V. Directly comparing it to the wt protein we found that it stabilizes the FIIND domain, leading to increased autoproteolysis and DPP9 binding...

Our story on NLRP3 priming is now out in Immunity after 5 years in the making. We found that IKKβ primes the inflammasome by recruiting NLRP3 to the trans-Golgi network. This allows the NLRP3 inflammasome to form independently of NEK7. Summary👇 authors.elsevier.com/c/1g5G03qNrUqG…

A big thank you to all collaborators: Haotian Chi, Katja Blumenstock Jonas Möcking, Martin Peter, Svergun Group, @belab.bsky.social, Christophe. Rouillon , Jonathan Schmid-Burgk , @gha14 for their contribution and great discussions. (3/3)

I am honoured to receive the #BayerPharmaceuticalsPhDAward. Thank you for this great recognition and thank you to the people who have contributed and supported me throughout my PhD journey x.com/GBM_eV/status/…

Weekend reads! Check out our preprints on #GSDMD pore formation. We generated #nanobodies and used them to dissect the steps of pore assembly (and more) in living cells, Anja Kopp Institute of Structural Biology Bonn solved structures (and more) Rheinische Friedrich-Wilhelms-Universität Bonn biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Exciting new work on #NLRP3 #inflammasome from fantastic PhD student Maria Matteo Tortola and her supervisor Ana Tapia Abellan. Maria discovered 2 parallel activation pathways, TGN/MTOC/cage dependent, and a new independent pathway! Thx 4 gr8 help from Institute of Structural Biology Bonn Institute of Innate Immunity! 👇

Four year lab anniversary marked by the first lab retreat. Feeling so lucky to work side-by-side with such an amazing group of people ☺️. Missing @AutomneNine patryk.ludzia hongmiao.

Excited to share our latest work and first venture into the chromatin field. We visualized for the first time that shelterin factor TRF1 binds and modulates telomeric nucleosome. hongmiao @AutomneNine Great collaboration with the Robinson's group science.org/doi/full/10.11…

On November 17, we are honoring the lives and careers of my PhD mentor, Kiyoshi Nagai and dear colleague, Chris Oubridge. Attendance can be either in person with limited numbers or on Zoom. See below for the registration details.

NEWS! I'm excited to share that I'm joining isb_bonn Uniklinik Bonn Rheinische Friedrich-Wilhelms-Universität Bonn ImmunoSensation as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com

We have ~£5000 worth of IBA Lifesciences resins which we have data to show they don’t work as well as previous batches. Without showing any data, the company insisted that their resins were fine and offered no replacement or refund. Anyone with similar experience or any advice?

Proud to share our latest work by the talented duo @AutomneNine and Zala Sekne on the 2.7 Å structure of telomerase H/ACA RNP with new insights into disease mutations and pseudouridylation. Assisted by the newest lab member during revision. rdcu.be/dwUyY

Come and join this amazing group of scientists to work at the cutting edge of structural biology of telomeric complexes. The LMB is a highly collaborative place. Please share!

Congratulations to Kelly Nguyen, who received the 2024 Colworth Medal at our UK DNA Replication meeting! It was fascinating to hear Kelly’s recent progress on the elucidation of the mechanisms of human telomerase #BiochemAwards

Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at Princeton in 2025. We are proud of you and thankful for all your contributions. Please watch out for exciting future opportunities from the Ghanim lab!