Now in #PAIN: “Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial” by Haidar Al-Khazali et al. bit.ly/3K0UtWd

.Haidar Al-Khazali et al. find that opening of KATP channels initiates cluster headache attacks during active phases, suggesting KATP channel blockers as potential drug target for cluster headache. Learn more in #PAIN bit.ly/3K0UtWd

Saturday news 🗞️ New study in Cephalalgia reveals migraine attack induction via cGMP-dependent signaling can occur even during #CGRP receptor blockade using #erenumab🧠 Read more: journals.sagepub.com/doi/10.1177/03… Bianca Raffaelli Messoud Ashina Hakan Ashina

🔬 New research paper finds hypersensitivity to BKCa channel opening in people with post-traumatic headache🧠 Targeting BKCa channels might open new avenues for drug discovery 💊Hakan Ashina Haidar Al-Khazali Basit Ali Chaudhry Read more here: …alofheadacheandpain.biomedcentral.com/articles/10.11…

HOPE trial: In adults with migraine and previous preventive treatment failures, a single infusion of a monoclonal antibody to pituitary adenylate cyclase–activating polypeptide led to fewer migraine days per month than placebo over the next 4 weeks. nej.md/4dQymPH

Exciting news! In 2009, our lab was the first to show that the signaling molecule #PACAP can trigger #migraine attacks 🧠 Now, a phase 2 trial confirms that blocking PACAP can prevent them! A big step forward in migraine #research 🌟 Read more: nejm.org/doi/full/10.10…

🧠The signaling molecule PACAP plays a key role in triggering migraine attacks. Discover how PACAP could reshape migraine treatment and bring relief to those in need 💡👇⁦Human Migraine Research Unit⁩ ⁦International Headache Society⁩ ⁦European Academy of Neurology⁩ ⁦European Headache Federation⁩ nature.com/articles/s4158…

New online! Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine go.nature.com/3Zn48PV

Migraine affects over one billion people worldwide, and new research highlights the role of PACAP in migraine pathogenesis. Targeting #PACAP signaling offers promising potential for future #migraine treatments #neurology #headache👇 rb.gy/oy7st2

Some triptans are a more effective treatment for acute migraines than newer, more expensive drugs, finds an analysis of the latest evidence Andrea Cipriani Includes a visual abstract #BMJInfographic bmj.com/content/386/bm…

Thursday News 🗞️ Excited to announce our latest paper in The BMJ: a network meta-analysis comparing 17 acute #migraine meds 💊. Eletriptan, Rizatriptan, Sumatriptan, & Zolmitriptan outshine newer #CGRP-targeted treatments 🧠bmj.com/content/386/bm… bmj.com/content/386/bm…

🚨News! I've been awarded a "Center of Excellence" grant by the Danish National Research Foundation. We're creating the Center for Discoveries in Migraine at Rigshospitalet-Copenhagen University Hospital. ⁦Rigshospitalet⁩ ⁦Danmarks Grundforskningsfond⁩ dg.dk/en/730-mil-dkk…

🧠✨ Exploring the mysteries of migraine aura! Our latest fMRI study reveals how CSD alters CBF during spontaneous attacks! ⁦JCBFM⁩ ⁦Human Migraine Research Unit⁩ ⁦International Headache Society⁩ ⁦European Headache Federation⁩ ⁦European Academy of Neurology⁩ ⁦American Headache Society⁩ journals.sagepub.com/eprint/EBE4HXN…

🔬 New study finds signs of cortical inflammation in migraine using quantitative MRI! 📊 Higher T2 values in the occipital cortex suggest edema or immune activation in those with migraine aura. 🧠💥 Read more here: onlinelibrary.wiley.com/doi/epdf/10.10…

A recent review on occipital neuralgia (ON), a severe and paroxysmal pain condition affecting the occipital nerves, analyzed data from 15 clinic-based studies involving 579 patients. ON shows female predominance and links with migraine and neck trauma. journals.sagepub.com/doi/10.1177/03…

🚨 New publication alert! 🧠 Our study just out in @BrainComms identifies clinical predictors of response to erenumab for migraine prevention. Chronic migraine, daily headache & past med failures = lower odds of benefit. Toward precision medicine! 🔍 👉 academic.oup.com/braincomms/adv…

Congratulations to the LF Fellows 2025! We are proud to announce that seven outstanding scientists have been awarded the LF #Fellowship. Each receiving a grant of DKK 10 million to immerse themselves in their scientific projects over the next five years: ow.ly/LKRh50VMYAP

🚨 Big news! We’ve received an Novo Nordisk Foundation Tandem Grant for #MIGRAINE — designing AI-powered GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud Ashina, Hakan Ashina, and Esperanza Rivera de Torre! 🧠 + 💊 + 🧬 = new hope.

🚨 We’re hiring a PhD student! 🚨 Join us at DTU Bioengineering + collaborators Messoud Ashina & Hakan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠. 🔗 Apply: lnkd.in/dCRU_EN3 🔍 Project: lnkd.in/dbpi8MwX

New study: IV infusion of substance P induced headache and arterial dilation in healthy adults. 71% reported #headache vs 10% with placebo. Findings support a role for substance P in headache pathogenesis #migraine #neurology #SubstanceP Cephalalgia shorturl.at/6l9vv