De novo protein design is great, but nature has millions of proteins- why not repurpose them? Introducing Raygun, a new approach to protein design. It allows you to miniaturize, magnify or modify any protein. We synthesized miniaturized variants of eGFP and mCherry! 1/

Bio foundation models are great design and engg tools. But can they help decode the fundamental principles of life? We harnessed a single-cell FM for decoding the long-debated relationship between genome arch. and gene coregulation. It all started with an idle curiosity. 1/

Glad to see our scGPT is helpful to many genomic researchers! 🙏🔥 Thanks for sharing this study!

At RECOMB-Seq, I will be presenting GLACIER, with Uthsav Chitra and my trainees Prannav and Huan Liang , where we introduce Spatial Granger Causal inference: decoding the drivers of tissue topology. It's a lovely RECOMB-to-RECOMB story, will tweet more soon. biorxiv.org/content/10.110…

Grad Sierra Strutz, mentor Anoop Mayampurath, UW + Loyola + UChicago +Northshore team developed a novel hospitalwide XGB model for the early detection of deterioration in children, thereby enabling a unified risk assessment throughout their hospital stays! pubmed.ncbi.nlm.nih.gov/40445617/