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New version of LukProt - a protein sequence db focused on early branching animals! With many more species, a preprint: biorxiv.org/content/10.110… And a BLAST server anyone can use: lukprot.hirszfeld.pl Download here: zenodo.org/records/7089120 #evolution

The GlycoWeb BBSRC sLOLA is recruiting! Please circulate to your networks and get in touch for more information. Proteoglycans GRC 2022 Glycobiology.UK Extracellular Matrix News SFGlycobiology Glyco@Alps

We are thrilled to present a new family of microbial mucinases that specifically recognize mucin O-glycan clusters and employ two glutamic acid residues for catalytic cleavage. nature.com/articles/s4192…

A reminder, we are currently searching for a #PhD and #postdoc to join us at the Center for Chromosome Stability in Copenhagen. The positions are fully funded. The deadline for the postdoc position is this Sunday (10.03.24). Details below:

Fushinobu, S. Taking a walk to find new mucinases. Nat Catal 7, 345–346 (2024). doi.org/10.1038/s41929…

Characterization of a cool mucinase subtype bearing features of both glycosidases and proteases ⁦Nature Catalysis⁩ #glycotime A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases | Nature Catalysis nature.com/articles/s4192…

Paper here: biorxiv.org/content/10.110… . Interesting stuff for the glyco-heads out there. 6-sulfated galactose polysaccharide induces this change somehow. Would be cool if someone could see if rosetteless (or another one of the choano lectins) binds the polysaccharide directly.

Interesting result tucked away in here that comparing a boutique protein language model (fewer seqs) to the big beasts like ESM-2 or ProtT5, scale wins out again.

academic.oup.com/glycob/article… Great stuff from the Aebi lab as usual!

📈 One standard graph in all bio deep learning papers should be: max similarity to anything in training set vs performance. (Reviewers shouldn't have to guess if there might be overfitting issues).

New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 doi.org/10.1016/j.bbag…

Look, I know I am in the medical faculty and all that, but I love this kind of paper SO MUCH. There’s so much here for me to dig into. Mucins(ish), Galectins and LEGO bricks, you couldn’t concoct a better nerd snipe for me.

I’m excited to announce the launch of our company KPL ApS , and website: kplbio.com.  The goal is to make some cool proteins, starting with proteases for #proteomics purposes ☺️. First product is the infamous LysC (lys.bio) but stay tuned more!