Have you ever asked yourself how myeloid cells are reprogrammed to become tumor-associated macrophages (TAMs)? Our recent publication International Journal of Cancer indicates a prominent role of DNA methylation in the epigenetic reprogramming of TAMs! onlinelibrary.wiley.com/doi/10.1002/ij… 1/n

🔥📢Read the new study led by our very own Editor-in-Chief C. Plass DKFZ and R. Scherz-Shourval Weizmann Institute on the epigenetic reprogramming of #TumorAssociatedMacrophages and their #DNAmethylation landscape 🔓➡️doi.org/10.1002/ijc.34… #breastcancer, #TumorMicroenvironment

Delighted to share our story about enhancer hijacking event! First contributing article of my PhD DKFZ . Many more to come hopefully 😉 nature nature.com/articles/s4137…

We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇. High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e… #epigenetics, #wgbs 🧵

Very happy that this is out! Thanks to the work of many passionate scientists from Academia, Industry and Clinics, to the generosity of #COPDpatients. High-resolution #transcriptomic and #epigenetic profiling ids novel #COPD regulators #Multiomics #humanLungFibroblasts

One in 400 people among the general population – and 1 in 40 Ashkenazi Jews – is born with mutations in the BRCA genes that increase the risk of several cancer types. It's not surprising then that these mutations keep cancer researchers busy. (1/3)

Epigenetisch wirkende Medikamente ermöglichen, dass Bereiche des Erbguts abgelesen werden, die vorher blockiert waren. Das führt zur Bildung neuer mRNA und neuer Proteine, die das Immunsystem beim Erkennen von Krebszellen unterstützen könnten. Uniklinikum Tübingen t1p.de/994hd

Congratulations to all authors involved in this beautiful study about Juvenile Myelomonocytic Leukemia! I am pleased to have contributed to this work that not only demonstrates the oncofetal reprogramming of this childhood cancer, but also identifies therapeutic vulnerabilities.

Trackplot: a fast and minimal dependency R script for epigenomic enrichment plots academic.oup.com/bioinformatics… github.com/PoisonAlien/tr…

Ashish Goyal, Jens Bauer und Joschka Hey erhalten den diesjährigen #WaltraudLewenzPreis für ihre Arbeit über die Identifizierung von Neoantigenen, die von neu aktivierten Transkripten bei epigenetischen Therapien kodiert werden. Herzlichen Glückwunsch! 👏 VomLaborInDiePraxis