Hematopoiesis News
@hema_news
An online resource for researchers studying hematopoiesis, blood, and bone marrow disorders. Part of the @STEMCELLTech Science News service.
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http://www.hematopoiesisnews.com/ 11-06-2010 18:33:13
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🩸 Scientists alongside Adrián Candelas show that specific heterotypic interaction with osteoblast and endothelial cell promote asymmetric division of human hematopoietic stem and progenitor cells. Brunet Stéphane THERY Manuel 📎 bit.ly/3X8jCWC
This review discusses seminal and recent studies that have advanced the understanding of mechanisms that drive selection for mutant #hematopoietic stem and progenitor cells in the 🦴 bone marrow niche. Journal of Clinical Investigation | bit.ly/4dS4yBZ
🔎 Investigators with Dr. Vilma Dembitz at Barts Cancer Institute (Queen Mary) identified stearoyl-CoA desaturase as prognostic of patients' outcomes and showed that SCD inhibition ⛔ is a therapeutic vulnerability across multiple #AML models. Leukemia Journal | go.nature.com/4g44ssH
Scientists at Erasmus MC demonstrated that nearly one-third of pediatric #AML cases had an #immune-infiltrated 🦴 bone marrow, which was characterized by a decreased ratio of M2- to M1-like #macrophages. 💉 Leukemia Journal | go.nature.com/3Xknl3u
🔬 Researchers uncovered a distinct and heterogeneous serine #metabolism within HSCs and identified mouse 🐭 HSCs as serine auxotrophs whose maintenance relies on exogenous serine and the ensuing #mitochondrial SHMT2-MTHFD2 axis. Cell Stem Cell | bit.ly/4cLFxHD
Scientists performed scRNA and scATAC-seq in #COVID19 patients with and without TET2-mutated clonal #hematopoiesis reasoning that the 🌡️ inflammation from COVID-19 may highlight critical downstream transcriptional targets of TET2 🧬 mutations. Cancer Discovery | bit.ly/4cK5p6w
Researchers used 🦴 bone marrow immune cell enrichment analysis from public databases to screen prognostic 🧬 #genes, construct prognostic models, and validate their prognostic significance on independent external datasets. Scientific Reports | go.nature.com/475miaS
Chromothripsis is an infrequent genomic phenomenon in pediatric T-ALL but is associated with cancer-predisposing syndromes and may associate with inferior prognosis, reports UMED Lodz (Uniwersytet Medyczny w Łodzi) researchers. 📖 @Leukemia | go.nature.com/4g6KY6N
Researchers at Soochow University demonstrate a crucial role for YAP1 in #thrombopoiesis, providing potential for the development of diagnostic markers and therapeutic options for immune thrombocytopenia. Read about their findings 👉 Blood Journal | bit.ly/3TgA98G
Let's kick this up a NOTCH... Drs. Shicheng Sun, Ali Motazedian, and team report the efficient generation of human NOTCH ligand-expressing hemogenic endothelial cells as infrastructure for in vitro hematopoiesis and lymphopoiesis. | University of Melbourne go.nature.com/3XAKNtu
👵👴 Dr. Marc Jan Bonder at University of Groningen developed scEpiAge, a single-cell DNA methylation age predictor and used it to highlight single-cell aging heterogeneity in mouse blood. go.nature.com/3ZeOWEv
ParkinsonsDisease (PD) is linked to increased odds of Clonal hematopoiesis of indeterminate potential with TET2 mutations, suggesting immune dysregulation in PD pathophysiology, according to a new paper by Seoul National University researchers. go.nature.com/3XvLK62