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Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

Introducing NEST, our deep-learning solution for detecting cell-cell communication on #SpatialTrascriptomics data at single-spot or #SingleCell precision! Pre-print: biorxiv.org/content/10.110… NEST: github.com/schwartzlab-me… NEST-Interactive: github.com/schwartzlab-me…

I am very excited to share our lab's first preprint Universitätsklinikum Heidelberg together with the Leuschner Lab. This study was led by @FloWuenne and Florian Sicklinger. biorxiv.org/cgi/content/sh…

I am incredibly happy to share that we have recently started the European Society for Spatial Biology (ESSB) European Society for Spatial Biology which will be hosting its first conference in Berlin 12-13 of December 2024: spatialbiologysociety.eu

Uh-oh 😬 KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of #PancreaticCancer nature.com/articles/s4159… Not the only preclinical model where this has been been described by the way journals.plos.org/plosone/articl… nature.com/articles/s4159…

🧬🙌🏻 Only a week left to submit your abstract for 'Quantitative biology to molecular mechanisms' – over 20 talks will be selected from abstracts, with a priority for early stage researchers, so don't miss your chance! #EMBLOmics ➡️ s.embl.org/omx24-01 📜 Deadline: 27 Aug

Our latest paper is out in nature! Hair follicle stem cells activate phagocytosis to clear apoptotic neighbours and maintain homeostasis👇🏼 Shout-out to Katie Stewart and everyone involded for the great work 👏🏼 nature.com/articles/s4158…

We are hiring! Please RT The Lunenfeld-Tanenbaum Research Institute is seeking candidates for four (4!) positions for a Principal Investigator. lunenfeld.ca Applications close Oct. 20. Medicine by Design Temerty Medicine U of T Emerging and Pandemic Infections Consortium gingraslab Donnelly Centre uoftresearch

Two great opportunities in Toronto! apply.interfolio.com/152420

Excited about spatial biology and Mass Spectrometry Imaging? Then explore and share the MALDI MSI workflow in Philippas preprint: biorxiv.org/content/10.110… CRC TRR332, 조수현, Am Soc for Mass Spec, #myeloidCells, #msimaging, Imaging MS Society

When can multicellular niches be learned directly from single-cell atlases? 🗺️ We explore this in our latest preprint, including a novel discovery-validation setup, a probabilistic model for inferring niches, and find links between KRAS variants and niches in pancreatic cancer!

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out Nature Biotechnology ! Read here👉: doi.org/10.1038/s41587… 🔬 Highlights: - Uses an experimental library of peptide markers integrated with a structural proteomics workflow. -

#qTAG: Laurence Pelletier Laurence Pelletier and coworkers present an adaptable set of optimized #CRISPR repair cassettes for streamlined endogenous tagging, enabling diverse applications in functional protein studies within their native regulatory context embopress.org/doi/full/10.10…

Which are the highest cited original research publications in #PancreaticCancer over the past five years (from 2020 to 2024 end)? All metrics obtained from Google Scholar (caveat: GS tends to OVERESTIMATE citations but the trends are consistent overall). 🧵 Below:

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Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

When do pathology images and spatial transcriptomics tell us different things about tumour biology? Our work on disentangled representation learning for paired pathology and spatial expression data will be presented as a spotlight at LMRL on April 28th at #ICLR2025

Nothing but sincere gratitude for the joint AACR-CIHR Scholar-in-Training award at this year’s annual conference! Feeling inspired and excited for our work now more than ever 🔬👩🏻‍🔬 CIHR AACR #AACR25