See our new paper 'TMEM161B modulates radial glial scaffolding in neocortical development'. Awesome job by Lu Wang, PhD, to find cause of human #polymicrogyria (i.e. too many brain folds). co-discoverer ChrisAWalsh youtube.com/watch?v=aLvJr6… pnas.org/doi/10.1073/pn….

I am thrilled to announce that I will join U of Utah Human Genetics in 2024! Looking forward to the fantastic research community and wonderful colleagues!!! Both dry- and wet-lab positions are available for genomic mosaicism in human health and development: sites.google.com/view/xiaoxu-ya…

Our new paper ‘Contribution of de novo mutations to #meningomyelocele’ is now at medRxiv. A 10-year effort to find causes for this mysterious and common ped-neuro disease. medrxiv.org/content/10.110…. Thanks to Spina Bifida Association, @NICHD_NIH and collaborators!

Our new ms “Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain” is now at nature . rdcu.be/dEmgT! We report on human forebrain dynamic assembly during development…1/n

Super excited to share our latest study on spinal bifida out today in @ScienMagazine amazing team effort from the Gleeson lab and collaborators, also huge thanks to the incredible support from Joseph G. Gleeson science.org/doi/10.1126/sc…

Chromosomal 22q11.2 deletions increase risk for meningomyelocele, one of the most severe and common forms of spina bifida, a new Science study finds. 📄: scim.ag/6PS

Chromosomal 22q11.2 deletions increase risk for meningomyelocele, one of the most severe and common forms of spina bifida, a new Science study finds. 📄: scim.ag/6Sz

New Insight Into Genesis of Spina Bifida today.ucsd.edu/story/new-insi…

biorxiv_devbio Check out our new biorxiv post focused on origins of neural crest-derived peripheral nervous system ganglia! We used mosaic variant barcode analysis to resolve clonal lineage in humans.

Thrilled to share latest preprint studying the events prior to trunk neural crest delamination using mosaicism, CRISPR barcode and live imaging. Thx support from my postdoc mentor Joseph G. Gleeson and amazing collaboration Xiaoxu Yang Melanie D. White, also @melaniedwhite.bsky.social biorxiv.org/content/10.110…

Preprint alert! Along with other cutting-edge approaches, read how Vong et al. used ResolveOME-enabled single nucleus DNA and RNA analysis, allowing for the simultaneous identification of cell type and genotype. biorxiv.org/content/10.110… #WhatQuestionsWillYouAsk

Our new study updates 50-year-old models of developmental #neuralcrest cell migration, using mosaic variant analysis in human, mouse and quail. Melanie D. White, also @melaniedwhite.bsky.social Harry Keng Ioi Vong Xiaoxu Yang biorxiv.org/content/10.110…

It was an absolute pleasure to join this exciting collaboration re-examining neural crest cell migration with Joseph G. Gleeson Harry Keng Ioi Vong & Xiaoxu Yang. And a great effort by Yanina & Jianxiong Wang 王建雄 to track in vivo NCC migration in the quail embryo Institute for Molecular Bioscience 🇺🇸🇦🇺🧍‍♂️🐁🐥

The next Ethel Browne Harvey Postdoc Seminar will be held Friday, February 14 at 3 pm Eastern Time featuring Yinan Wan Yinan Wan from @Biozentrum and Keng loi Vong from UC San Diego. Register today and join us. bit.ly/3zXSHE3 #SDBPostdocSeminar

Don't miss next Ethel Browne Harvey Postdoc Seminar this Friday, February 14 at 3 pm Eastern Time featuring Yinan Wan Yinan Wan from @Biozentrum and Keng Ioi Vong Harry Keng Ioi Vong from UC San Diego. Register today and join us. bit.ly/3zXSHE3 #SDBPostdocSeminar

Check out our new paper in @nature nature.com/articles/s4158…. We report genetic mechanisms of neural tube defects in patients. Spina bifida is also known as meningomyelocele (MM). Prior family-based and association studies found few linked genes, so we took a different approach.

#DBfeature #InMemoriam Remembering Dr. Paul Kulesa's (1962–2025) pioneering work on neural crest development, which has profoundly impacted neuroscience & pediatric cancer. A huge loss to the DB community. His recent work on chick & mouse neural crest. sciencedirect.com/science/articl…

I’m super honored to receive this transition grant award from Simons Foundation also huge thanks to the unwavering support from Joseph G. Gleeson and team!

Check out our new resource paper Cell Stem Cell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L96tu0Ctj…

Thanks Joe! This won’t be possible without your mentoring and unwavering support!