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Our spatial multi-omics technology that co-profiles five modalities is now published in Nature Methods Nature Methods! Huge thanks to Marek Bartosovic, Mingyao Li, and my amazing team, including postdoc Pengfei_Guo and PhD student Liran Mao! nature.com/articles/s4159…

🚨 New paper in nature! 🚨 We’ve mapped the human hypothalamus in unprecedented detail, revealing key differences from mice & unlocking insights into obesity, metabolism & drug development. Meet HYPOMAP—a cellular Google Maps for the brain’s metabolic control centre. 🧵(1/)

Transcriptome- & proteome-wide association Mendelian randomization study for heart failure in MVP data (N=420,000)🧬 Promising data on potential causal proteins 👉70 for HFrEF 👉10 for HFpEF A really comprehensive example of follow-up assessment of drug target potential👇1/3

Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues Joseph C Wu, MD, PhD, Sakthivel Sadayappan, PhD, MBA and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug

Important reads from this week on human genetics, multiomics, and precision medicine🧵 1⃣A new expression and splicing QTL resource from TOPMed In 14,324 whole blood and tissue samples, the study detects primary and secondary cis- and trans-e/sQTLs and colocalizes them with

Congrats to Min, Yanzhu and Xubin. We invented two cool methods for profiling nearly genome-coverage single-cell histone marks in embryo dev. Single cells with 6 histone marks allow for epigenomic lineage tracing and pinning point cell2cell diff...nature.com/articles/s4158…

Nature research paper: Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide go.nature.com/43jKIgV

Join us for the upcoming Weekly Research Conference, featuring Dr. Sean Wu (Sean M Wu, MD PhD). 📅 Monday, March 24 ⏰ 12:00 EDT 👉 Register now: ow.ly/RZW250VhlLK Stanford CVI

In this Review, Eliana Nehme, Amitesh Panda, Isabelle Migeotte & Vincent Pasque give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies. journals.biologists.com/dev/article/15…

Issue 5 is complete! Cover: 3D reconstruction from light-sheet fluorescent microscopy image stack depicts parallel networks of vessels (PECAM1+, CD31, magenta) and nerves (PRPH+, yellow) in a human heart at 10.0 post-conceptional weeks. See De Bono et al. doi.org/10.1242/dev.20…

Happy to share our StemCellReports review on examining 🫀noncoding variants in hiPSCs is now online. Importantly, we provide a resource summarizing epigenomic datasets (see thread for GSE IDs) in hiPSC-based cardiac models for the scientific community cell.com/stem-cell-repo…

CytoSimplex: Visualizing Single-cell Fates and Transitions on a Simplex academic.oup.com/bioinformatics…

New online! Transcriptomics in the era of long-read sequencing bit.ly/3FG0rwU

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions Read this Techniques & Resources Article by Anna Nordin, Gianluca Zambanini, Mattias E. Jonasson, Pierfrancesco Pagella Claudio Cantù & co.: doi.org/10.1242/dev.20…

CHOIR is now online Nature Genetics! CHOIR is a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR scales to millions of cells and works with single-/multi-omic data of any type! nature.com/articles/s4158…

Join us for the upcoming Weekly Research Conference, featuring Dr. Hee Cheol Cho. 📅 Monday, May 5 ⏰ 12:00 EDT 👉 Register now: ow.ly/7C2550VKCoW

New! Online now: Fasting-induced ketogenesis sensitizes bacteria to antibiotic treatment dlvr.it/TKVFsK

Wonsuk in my lab and Xiyu in Qin Yang's lab discovered NaR as an alternative NAD precursor, made by the liver-kidney axis, published in Cell Metabolism. Congrats all! sciencedirect.com/science/articl…