If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of MitotypeExplorer.org Feedback welcome!

G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation: cell.com/molecular-cell…

Protein codes promote selective subcellular compartmentalization | Science science.org/doi/10.1126/sc…

🚨📰TWEETORIAL time📰🚨 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagenesis of the MYC TAD (~3 Mb) in 6 different human cancer cell lines nature.com/articles/s4146…

Our paper "Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function" is now published in Nucleic Acids Res doi.org/10.1093/nar/gk…. This work was led by our super postdoc Sheng-Jia Lin * Several papers on F0 mutagenesis have been

Sharing our new paper on rare damaging CCR2 variants that we found to be associated with protection against atherosclerotic cardiovascular disease🧬🫀❗️ A short thread about the topline findings🧵

I'm co-Guest Editing a special Collection in Genome Medicine with Clint Miller and we warmly invite you to submit your work! From #multiomics & #AI to #regenerative medicine - this Collection focuses on decoding #CardiometabolicDisease @https://biomedcentral.com/collections/5203

It’s a wrap! Big thanks to all the speakers and attendees for sharing great science and vibrant networking at the Finnish Society of Atherosclerosis meeting during the last two days. See you next year in Turku, June 11–12, 2026! 🇫🇮🫀 #Atherosclerosis

Perturb-seq enables analyses of the single-cell transcriptomic underpinnings of gene knockouts❗️ X-Atlas/Orion is a publicly available dataset that scales perturb-seq to unprecedented levels👇 [1/4]

First, Google DeepMind put structural biologists out of work, and now it's coming for the jobs of bioinformaticians doing genome analysis: a preprint reveals AlphaGenome, the little brother of AlphaFold. biorxiv.org/content/10.110…

Principal Investigator Joshua Mendell (Joshua Mendell) and researchers at UT Southwestern Medical Center highlight the functional versatility of snoRNA sequences and expand the known mechanisms through which noncoding RNAs orchestrate ribosome biogenesis. cell.com/molecular-cell…

I am always amazed by the diversity of wrong ideas clinicians have about #VUS Today's one is unique- a clinician (a senior one) telling me that VUS is a low quality variant , and is there in the report because it was possibly not covered deep enough. #MedTwitter #genetics 1/3

Some mitochondria puff out their content into the cytoplasm, exhibiting localized membrane distentions. This may contribute to inflammatory responses, for examples.

Latest genomic AI models report near-perfect prediction of pathogenic variants (e.g. AUROC>0.97 for Evo2). We ran extensive independent evals and found these figures are true, but very misleading. A breakdown of our new preprint: 🧵

Grateful to be part of this exciting study and collaborate with a fantastic team of Rajender Motiani lab in exploring the interconnected roles of ORAI3, NFATc1, and MARCH8 in understanding of cancer biology. #CancerResearch #zebrafish

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

New Roche sequencer being tested for same-day genome interpretation in neonatal ICUs: "In the case of blood samples that arrived at the laboratory by 7 a.m., we obtained an interpreted report between 2 p.m. and 4:30 p.m. the same day." nejm.org/doi/full/10.10…

The functional impact of 17,000 (!) missense LDLR variants on LDLR cell-surface abundance and LDL uptake and their effects on hyperlipidemia phenotypes Science Magazine

After two years of work, we’ve made an AI Scientist that runs for days and makes genuine discoveries. Working with external collaborators, we report seven externally validated discoveries across multiple fields. It is available right now for anyone to use. 1/5

Our PLAMseq paper is out today in Science Advances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci. science.org/doi/10.1126/sc…