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We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.

Hi! I’ll be speaking at Harvard Medical School Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Devin Schweppe @oligopain Shao-En Ong Alessandro Bertero Just think about all the microcompartments in a nucleus—speckles, enhancer hubs, transcription condensates, chromocenters, repair foci, etc. Are all compartments of a given type the same? Or do individual compartments adapt to the specific needs of the loci they touch? (6/30)

Functional coupling across long physical distance via RNA looping. Solid single molecule evidence and interesting idea 💡

In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹 Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

Everything you love about generative models — now powered by real physics! Announcing the Genesis project — after a 24-month large-scale research collaboration involving over 20 research labs — a generative physics engine able to generate 4D dynamical worlds powered by a physics

Prof. Nikolai Slavov Research must strive to seek the truth, yet many pursue narratives and story-building. And so, here we are. Interestingly, normal tissues have been found to harbor driver mutations without leading to malignancy. A famous example is BRAF p.V600E.

I have a theory: the amount of information provided in the context differs significantly for these two types of agent scaffolds. And this causes the reasoning model like o1 to perform differently. Reasoning models are trained to THINK hard, e.g., by solving extremely

My lab at Brown University is hiring a postdoctoral fellow! We develop single-molecule imaging technologies to dissect the spatial regulation of gene expression. For more information about my lab, visit weihan-li.com Please help spread the word! #RNA #imaging

Distilling the potential impact of science based on a title is so dangerous. Some of the biggest biomedical breakthroughs came from research that, at first glance, seemed ‘pointless or unrelated. Here are a few that I'm sure might have caused an uproar in the headlines:

PhD programs are pausing admissions to graduate school due to NIH indirect cost cuts. See the growing number of programs here: docs.google.com/spreadsheets/d… How is science supposed to advance with fewer trainees, less $ for research? This is devastating.

So what's happening with medical research in the US? This is the cumulative award count from the NIH for the year. Doesn't look so good. But it gets worse. 1/

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer

Just learned that UM Medical School "was the first to have medical professors who were full university faculty (1850), the first to open a university-owned hospital (1869), the first major medical school to admit women alongside men (1870) and the first to require clinical

🚀 Our perspective is out in nature! We present a roadmap for Multimodal Foundation Models (MFMs) — large AI models pretrained across multi-omics and multi-timepoint data — to serve as the computational backbone for building virtual cells. Read the full paper in Nature:

Thanks Nils! Thanks Michigan Biophysics ! Super honored!

Please check out our new #Bayesian method for simultaneous #particletracking, #phaseretrieval, and point spread function reconstruction. Now on bioRxiv: doi.org/10.1101/2025.0…

I'm so grateful to this award and all the solid training I got from Nils Walter Lab and Michigan Biophysics !! Will keep going with I have learned here! Go blue!

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation: Molecular Cell cell.com/molecular-cell…