pharmacophore-optimized photoaffinity fragments-based hit discovery with improved hit rate and better sensitivity, and multiple binding sites, reported by RCNS MedChem Research Group Gunning Group nature.com/articles/s4200…

Congratulations to our Sr. Researcher Associate Mulu Geletu for receiving the Rosemary Brown Outstanding Mentorship Award at Canadian Black Scientists Network's #BlackExcellenceInSTEMM conference!! Mulu's commitment to scientific mentorship in our community is nothing short of inspiring. #BESTEMM2024

We're hiring a #Postdoctoral Fellow in #medicinalchemistry in collaboration with HDAX Therapeutics! Please repost and apply below if you're interested in advancing our novel small-molecule therapeutics! #chemjobs #chempostdoc #postdoc #postdocjobs ChemPostdocBot linkedin.com/jobs/view/3992…

Congrats to Motasem in the #Prosserlab and our recent co-supervised alumnus Geordi Frere for publishing a new story on tryptophan-based 2D 19F-13C NMR in RSC Chemical Biology!

🗞️ "Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F–13C two-dimensional NMR" ⤵️ University of Toronto &+ With #NSERCsupport.

Check out our paper on proton pump inhibitor activation in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (Tobias Dick). More collabs between our groups DKFZ to come! rdcu.be/eaDjn

Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.102…

In case you missed it: 'Microwave-assisted synthesis of pomalidomide building blocks for rapid PROTAC and molecular glue development' Fom Patrick Gunning and colleagues at Gunning Group buff.ly/FMUUweh

NEW SITE LAUNCH! braincancercanada.ca NEW! Researchers & Scientists: braincancercanada.ca/researchers-an… NEW! Patient & Caregiver Resources braincancercanada.ca/patient-caregi… NEW! Projects Funded braincancercanada.ca/projects NEW! Community braincancercanada.ca/community #braincancer

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM