Our latest paper exploring how MYC-MAX and CLOCK-BMAL1 engage with chromatinized E-boxes is out nature: rdcu.be/df8qh. We thank all the collaborators for their valuable contributions! Jerome Menet @partchlab Beat Fierz Schübeler Lab @johannes_zuber, Becker lab & Liu lab

Start the engines!

The genetic architecture of protein interaction affinity and specificity @AlexBendel_ + Guillaume Diss + Andre Faure @ajfaure.bsky.social quantified how mutations alter binding of a protein to all its possible interaction partners to understand specificity encoding biorxiv.org/content/10.110…

Extremely simple biophysical models do surprisingly good genetic prediction in sequence spaces >10^10, suggesting that vogue deep learning models may be unnecessarily complex. New work + scientific debut for Aina Martí-Aranda w/ cristina hidalgo-carcedo & Ben Lehner biorxiv.org/content/10.110…

Junior Group Leader position in Genome Biology Centre for Genomic Regulation (CRG). pls RT. Very open call. Quantitative and AI approaches particularly encouraged. recruitment.crg.eu/content/jobs/p…

New preprint from Andre Faure @ajfaure.bsky.social Centre for Genomic Regulation (CRG) Wellcome Sanger Institute MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis and allostery from deep mutational scanning data biorxiv.org/content/10.110…

🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷‍♂️ Robb Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇 biorxiv.org/content/10.110…

📢We're now accepting applications for our #PhD and #MDPhD programs! 🧬Join us in Basel, Europe's top hub for the #lifesciences, and unleash your potential in a vibrant, international and supportive environment 📅Apply by May 1 at bit.ly/FMIspring2024 #AcademicTwitter

Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju

The Ed Fischer Prize is awarded to @AlexBendel_ for investigating how proteins interact with each other, using advanced methods to study millions of these interactions. The committee was impressed by the research complexity and Bendel's strong leadership in the project.

Really proud of my first PhD student @AlexBendel_ for winning the award for the best thesis of 2023 at FMI science!!!

We will be hiring 👇 - apply if you are interested in understanding mechanisms of developmental timing using genomics, genetics, molecular biology, quantitative time lapse imaging, modelling, ...

We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related. Please forward to potential candidates and RT 🙏 More details below 👇

Our paper on deep mutagenesis of JUN’s interaction with the 54 human bZIP is now out in Nature Communications rdcu.be/dWXmn Great work from @AlexBendel_, with Andre Faure @ajfaure.bsky.social and Ben Lehner Thread in quoted post 👇

The genetic architecture of protein interaction affinity and specificity nature.com/articles/s4146… by Guillaume Diss @AlexBendel_ + Andre Faure @ajfaure.bsky.social

In a new study published in Nature Communications, researchers led by Guillaume Diss have provided key insights into how protein interactions are governed and how mutations influence cellular functions—work that might help advance personalized medicine. fmi.ch/news-events/ar…