Guide RNA-mediated RNA modification is more complex than previously thought. A #snoRNA can be active on artificial substrate RNAs but not on the same sequences in endogenous RNAs, such as #rRNA or spliceosomal snRNAs. #pseudouridine 📰⏬ bit.ly/3gRgkl9

The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons biorxiv.org/content/10.110…

Excited to share a new line of work led by Yale Interdepartmental Neuroscience Program student Paul Lee collaborating with Alexa Soares Marina Picciotto, in which we found a translational switch regulating the dual identities of synaptic organizers‼️ Yale Neuroscience Yale Psychiatry @YaleRNA Yale Kavli Institute for Neuroscience biorxiv.org/content/10.110…

💥Our new preprint! Transposon ADDICTION in development! Gag proteins of endogenous retroviruses are required for zebrafish development Study led heroically by Sylvia Ni & Jonathan Wells This work has transformed my view of transposons, no less! 🧵1/n biorxiv.org/content/10.110…

Thank you for the spotlight Yale Kavli Institute for Neuroscience, I'm extremely lucky to be part of such a supportive community!

After a brief hiatus, I'm thrilled to share exciting news: a new publication from our lab has just been released in the Journal “Nature Communications”. Here is the link: rdcu.be/dCEDN

I am thrilled to see our latest work online in Nature Communications! Our study sheds light on how social cues influence the production of extracellular vesicles (EVs) in worms. Males pheromone boosts EVs, while Herms dampen it. nature.com/articles/s4146…

I hope that everyone has the opportunity to mentor someone as talented as Xueying Shang. It requires immense dedication, creativity, enthusiasm, and maturity to advance the frontiers of biology. Congratulations to her for the hard work compiled into a wonderful publication 👇

How do cells maintain a balance in ribosome protein (RP) expression? We found genetic compensation between a pair of RP paralogs, mediated by a circular stable intron during spermatogenesis. Excellent work by Amanda Ng (former student) cell.com/cell-reports/f…

I’m excited to share a pre-print from our lab describing how an ultraconserved long noncoding RNA functions as a unique ribosome assembly factor. This work was led by the talented postdoc Jong-Sun Lee (not on X). Here's a brief 🧵 with the key findings 1/-biorxiv.org/content/10.110…