Happy to share two new preprints from our group at RTI International and collaborators covering DNA methylation and gene expression differences associated with alcohol use disorder in human brain. medrxiv.org/content/10.110… medrxiv.org/content/10.110…

Glad to see our paper, with Xin He Matthew Stephens Wes Crouse Sheng and Kevin, is out today at Nature Genetics! nature.com/articles/s4158…. We developed a new statistical method, causal-TWAS or cTWAS, to reliably identify causal genes in genome-wide association studies (GWAS). 1/n

Lessons from Blood Donors: your blood not only saves lives, but it is teaching us more about human biology at a scale that just 10y ago was unthinkable. Here we learned something new about genetic and biological factors regulating kynurenine metabolism news.cuanschutz.edu/news-stories/c…

#TeamMassSpec We're recruiting postdocs to work on new methods to map proteome remodeling due to chemical perturbations, aging, development, and more! If you're interested, see the job posting: ap.washington.edu/ahr/position-d… and some of the lab's projects: schweppelab.org/projects

Another interesting discovery from Angelo D'Alessandro: L-carnitine as an important factor in RBC metablism. Supplementation of stored RBCs with L-carnitine as a strategy to improve RBC storage quality? tinyurl.com/yjkmwskc

Check out the latest version of our paper on genetic and biological determinants of (RBC) glycolysis. Peer review is definitely making the paper better, and we hope this version will finally be out soon! biorxiv.org/content/10.110…

Super excited to introduce the RGC-ME paper nature.com/articles/s4158…! We describe the largest catalog of human protein-coding variations to date from exome data of ~1M individuals generated using a single harmonized sequencing and informatics protocol.

Chelsea's latest in collaboration with Jose L. McFaline-Figueroa and @GarciaLabMS's groups (thanks!) defines differential remodeling of cellular proteomes after epigenetic inhibition! This paper has 'everything': ☑️proteomics ☑️phos ☑️transcriptomics ☑️thermal stability ☑️histone mods

Preprint alert: Ferroptosis regulates hemolysis in stored murine and human red blood cells If there is a paper from our lab you will read this year, make it this one. biorxiv.org/content/10.110… thread follows - 1/10

What do RBCs without mitochondria do with carnitine? Now out in @BloodJournal. I am finally ready to share the backstory behind this article. It's a story on how we keep reinventing the wheel, and how "old school" biochemistry freaking rocks! ashpublications.org/blood/article-…

Excited to share our recent study on Biological and Genetic determinants of Red Blood Cell Glycolysis, now out Cell Metabolism - cell.com/cell-metabolis…

Quantgen folks looking for next event after ICQG2024: Registration is open for Gordon Research Conferences on Quantgen and genomics (16-21 Feb 2025 in Lucca, Italy), pls register! Program is online, and we have a great speaker lineup grc.org/quantitative-g…

Easy reporting of gene-by-treatment (GxT) or gene-by-environment (GxE) effects on RNA-Seq or other molecular count phenotypes described in a new preprint by my student Yuriko Harigaya with Michael Love : biorxiv.org/content/10.110…

RBCs from poor storing mice make good storing RBCs store poorly as well. A cellular cross-talk, a "good apple, bad apple" effect. Not as flashy as other recent papers I posted, but there is some cool fundamental biology at play here - with James Zimring dx.doi.org/10.1111/trf.17…

Blood donors offer a window into "healthy" aging. Now out Aging Cell, we report that arginine metabolism in >13k blood units, 587 sickle cell patients and 525 diversity outbred mice was linked to donor and RBC age, vesiculation and transfusion efficacy doi.org/10.1111/acel.1…

Thanks to all involved, Julie A Reisz Haines Travis Nemkov University of Colorado Anschutz, Steven Spitalnik Eldad Hod Columbia University, James Zimring UVA, Grier Page Greg Keele RTI International, Mark Gladwin University of Maryland, Baltimore, Mike Busch and Philip Norris Vitalant, Gary Churchill The Jackson Laboratory, Nareg Roubinian UC San Francisco

Now out @BloodJournal: Ferroptosis regulates hemolysis in stored RBCs. We identify STEAP3 (p53 target) as a key driver of stored RBC hemolysis by Fe-dependent lipid peroxidation Greg Keele James Zimring Brent Stockwell Gary Churchill The Jackson Laboratory Grier Page doi.org/10.1182/blood.…