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Not bad today, Seattle!

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence biorxiv.org/cgi/content/sh… #biorxiv_immuno

👾 🦠🚨NEW PAPER ALERT!🚨🦠👾 I am thrilled to announce that our work on cancer cell resistance to killer T cell attack was published as the cover article Science Magazine today. More info in the thread below. 1/ science.org/doi/10.1126/sc…

Our paper, "Inflammasome activation in infected macrophages drives COVID-19 pathology" is out. We describe macrophage infection by SARS-CoV-2 and the subsequent inflammasome activation as a contributor of lung pathology in COVID-19. disq.us/t/477wt29

Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now Cell Cell Press cell.com/cell/fulltext/… 1/15

Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche dlvr.it/SQ9VhG

Proud that our data on single cell profiling of immune cells in human lymphoid and mucosal sites with Peter Sims is part of the cross-tissue immune cell atlas through our cross-Atlantic collaboration @Teichlab Cecilia Domínguez Conde @CambridgeNeuro1 CZI Science science.org/doi/10.1126/sc…

First real world effectiveness study of Paxlovid and Molnupiravir: significant reduction in disease progression & all-cause mortality vs matched controls, more for Paxlovid, during Hong Kong BA.2 wave. Fast viral load reduction medrxiv.org/content/10.110… Carlos KH Wong Gabriel Leung

😍 OUT TODAY Nature Genetics 📰 Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation 🧑🏿‍🤝‍🧑🏽 Eddie Garcia Blagoje Soskic Gosia Trynka and team 👇🏿 go.nature.com/3lIzhsa

A brave, exciting, inspiring, and IMO necessary experiment in reimagining how we communicate and distribute science.

Huge day for the team here. And only the tip of the iceberg for things to come.

Mind-blowing. Myself ca. 1990 is totally in control now and freaking out.

Super cool. If you look close enough, immunology and biology always have more lessons to teach you, even in well-trodden areas.

Congrats to my brilliant student Aislyn Schalck and our wonderful collaborators Chantale and Don ⁦MD Anderson Cancer Center⁩ on our new study on TIL diversity in PDAC published in Cancer Discovery this week! aacrjournals.org/cancerdiscover…

New version of our comparison of transformations for single-cell data is on biorxiv.org/content/10.110… 🥳🎉 We completely revised the paper. Across three benchmarks, we show that, despite its theoretical shortcomings, no transformation consistently outperforms log(y/s + 1) 🤯

Beyond excited to share our new preprint exploring the therapeutic potential of manipulating Stat5 in exhausted CD8 T cells. Big thanks to all the co-authors,E. John Wherry our outstanding collaborators, and Parker Institute for Cancer Immunotherapy for their support!! 🧵biorxiv.org/content/10.110…

Congrats to the team esp Allen Institute for immunology (Claire, Zach, Pete) and Penn Sarah Henrickson Laura Vella E. John Wherry on this multi-omic human T cell dataset w/TEAseq, deep dive into naive T cells across age. Really fun collab, lots of data to mine.

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A pleasure to contribute a small bit to this really cool story. Congrats Joseph Collins Joel Boerckel!

Really fun, interesting collaboration with great scientists. Congrats to Rodney, David, and the rest of the authors!