Really interesting new paper from Akbari et al. identifying a lot more selection in ancient DNA than previous approaches. I think it gets at three core challenges for this type of analysis where our understanding is still limited. 🧵

Estimation of demography and mutation rates from one million haploid genomes biorxiv.org/cgi/content/sh… #biorxiv_genomic

Excited to share this new preprint with @spence_jeffrey_ and Doc Edge in which we developed a method to infer demographic history and mutation rates from millions of genomes, and applied it to gnomAD v4 data. Read on for a brief thread! biorxiv.org/content/10.110…

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Inferring human prehistory from genetic data [this thread] 3.4: Ancient DNA [next thread] web.stanford.edu/group/pritchar…

Chapter 3.4 describes how ancient DNA has reshaped our understanding of the human past.

#PrivateEquity owned Global Medical Response is also one of the biggest funders of #Prop35. The same PE firm that bankrupted Toys R Us is coming for our Medi-Cal program. #NoOn35 Health Access CA @JimWoodAD2 CPEHN CourageCalifornia

Looking for examples for class of STRUCTURE-style bar plot of hunter gather, early farmer, and steppe ancestry proportions for Europeans. Arranged temporally to shows various turn overs. Looking for something broad in temporal scope but simple enough to talk undergrads through.

I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.110…) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s4158…). A few surprising findings summarized here: 🧵