Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.110…

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with Jane Kondev Rob Phillips Hernan Garcia. 20 years later we can measure them: nature.com/articles/s4158… Thank you William J. Greenleaf Benjamin Doughty Michaela Hinks Julia and all co-authors!

Check out our new review of molecular recording, exploring cutting-edge technologies and their transformative potential for biology. A collaborative effort across multiple labs—proud to have been part of this amazing team! 🌟

How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/f…

The Kappel Lab is opening soon at UCLA and we’re hiring Staff Scientists to help lead our wet-lab projects & to assist with lab management! We have open positions for candidates with a PhD & for recent college grads. Learn more and apply: forms.gle/76inzTL6FoTcRP… Please RT!

The amount of bizarre political advertisements on my feed is getting out of hand 😳 is it finally time to swap platforms? I am kedmonds.bsky.social, I’ll try to re-add people there too (this feels like getting a new phone in the 2000s).

In the latest issue! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins dlvr.it/TK21Y8

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

🚨New paper alert!🚨 Cells integrate signals into decision-making. But how do levels of signaling influence cell-fate transitions? Is more always better? Or is there an “optimal” level for cell-fate programming? If we could tune signaling, could optimize production of neurons?

The Wilkinson Lab is open for science! Memorial Sloan Kettering Cancer Center 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

Hot off the press! Our latest paper led by Fernando Rossine , understanding how plasmids evolve inside individual cells. These small pieces of self-replicating DNA live inside bacteria and can transfer antibiotic resistance genes, but they also compete with one another to replicate. 1/