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🚀 Just published on bioRxiv! 🔍DiffInvex evolutionary model for conditional somatic selection✅ 🧬A genomic study of 10,000 cancer whole genomes identifying chemoresistant genes (putative therapeutic targets)✅ 👨‍💻DiffInvex soon on GitHub⌛️ 📄: biorxiv.org/content/10.110… (1/7) ⬇️

🎉Liza's paradoxical paper is out in Nature Comms: nature.com/articles/s4146… The short of it: ➡️driver CNA gains in tumor suppressor genes ➡️driver CNA losses in oncogenes ➡️some negative selection on oncogenes + comprehensive, data driven classification of cancer genes by CNA

Our pre-print "Comparative evaluation of methods for the prediction of protein-ligand binding sites" is out on Research Square. Check it out! 🔗 tinyurl.com/Utges-LBS-comp On this paper we benchmark 11 ligand binding site prediction tools on our curated reference dataset: LIGYSIS!

❓Want to learn an easy trick to improve your mutational signatures? ‼️Extract them from SNV and indel mutations jointly! A study by our Patricia F. Patricia Ferrer Torres now online, focusing on HR deficiency signature SBS3🧬 Here is a TL;DR for you 👇 (1/3)

🆕‘Detective’ Algorithm Predicts Best Drugs for Genetic Disorders and #Cancer Researchers at #IRBBarcelona & Centre for Genomic Regulation (CRG) publish in Nature Genetics a new computational model able to predict which drugs will be most effective for some diseases. ➡️bit.ly/4fUbS1x

🧬asymmetry in the cancer transcriptome? A new preprint by Guillermo Palou Márquez and Pere P from the lab has dropped on biorxiv TLDR: in tumors, allele-specific expression (imbalance between 👩‍💼maternal and 👨‍🔧paternal allele in mRNA levels) is commonly seen in cancer genes... (1/2)

New pre-print out! 👨‍🔬 🔗biorxiv.org/content/10.110… Here, we studied the incidence and impact of allele-specific expression (ASE; imbalance between two alleles in mRNA levels ⚖️) in tumorigenesis. 1/6

Weird. The logo was one of the good things about IRB Barcelona

Our paper on "Comparative evaluation of methods for the prediction of protein-ligand binding sites" is now available on Journal of Cheminformatics! Check it out: tinyurl.com/Utges-LBS Check thread below for main results. Thanks to everyone that helped. Geoff Barton Barton Group

The SNSF applauds the conclusion of the negotiations with the EU. Researchers in Switzerland can participate in almost all calls for proposals in the 2025 programme year of #Horizon Europe under a transitional arrangement. ➡️ lnkd.in/dViBEy_5

Meravellós article d'Arcadi Navarro 🎗 al diariARA, en memòria d'en Joan Guinovart. El millor homenatge que li podem fer és no oblidar-nos dels principis bàsics. Excel·lència, visió de futur i, per sobre de tot, lluita contínua contra una burocràcia infame que sembla dissenyada per

Double PhD defense day in the lab 🤩 Congrats to our dr. Guille Palou Guillermo Palou Márquez, fresh from the oven 🎊🥳 and similarly so our newly-minted dr. Ignasi Toledano Ignasi Toledano! Amazing defense both, bravo 👏👏