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A person with LFS carries a pathogenetic variant in their TP53 gene associated with an increased risk of cancer. To find out more about LFS and current research, including the MILI clinical trial: MILI tinyurl.com/nu3w4ba3 The George Pantziarka TP53 Trust Oxford Cancer #LFS

We are proud to announce a new co-funded research project with CCLG 🧪 The study, led by Dr Pardo Imperial College London, will replicate osteosarcoma cells travelling through the bloodstream to understand how this aggressive bone cancer spreads. Visit: ow.ly/3vx250VACeu

Hot off the press - 'Genetic predisposition in sarcomas: clinical implications and management'. Very happy to have been a co-author of this paper. sciencedirect.com/science/articl…

🧬 Genetic Predisposition in Sarcoma Up to 20% #sarcoma may be assoc. with predisposition genes In our 📝 we review evidence on genetic predis. & how it may influence Rx decisions & management inc. surgery, radiotherapy, systemic Rx & surveillance 1/4 thelancet.com/journals/eclin…

Women with Li-Fraumeni syndrome have a higher risk of developing breast cancer - early detection saves lives. This LFSA Legacy of Hope webinar will focus on breast cancer screening, including why it's important, how it works, risks, who should get screened and types of tests

In partnership with Boston Children's and Dana-Farber, the LFSA 5th International Youth Workshop will be held August 15-17, 2025. A cornerstone of Legacy of Hope, this unique experience for youth with Li-Fraumeni syndrome (LFS) empowers them to make lifelong peer connections.

It's been an amazing first day at #iDR25 exploring how we can unlock the potential of existing drugs for patient benefit. It's the poster presentations now, the #REMEDi4ALL booth is buzzing, and we're all set for Day 2!

A MILI Milestone: 30 participants randomised onto the trial! Thank you to all our recruiting sites for your support of the trial. OUH, Guy's and St Thomas', Cambridge University Hospitals NHS, @nottmhospital, NHS Grampian, University Hospital Southampton 💙, Leicester's Hospitals #TP53 #LiFraumeniSyndrome #LFS

Patient organisations on the panel sharing their experience in repurposing medicines - the hurdles and the path to success. On stage: CLOVES Syndrome Community, Mission: Cure, The George Pantziarka TP53 Trust, Volwassenen, Kinderen en Stofwisselingsziekten (VKS) and Lorna Pender.

It was a great pleasure to present at #iDR25 - especially about #LiFraumeniSyndrome and the MILI trial - linking drug repurposing as a way to reduce cancer incidence in a genetic predisposition. Thank you to all at REMEDi4ALL for a fantastic conference

#iDR25 – That’s a wrap! 🌍 300+ joined us in Amsterdam for two days of panels, posters, and powerful discussions on smarter routes to repurposed medicines. 👥 Thanks to our speakers and attendees for your insights, energy & contributions. 📖Highlights: remedi4all.org/idr25-wraps-up…

🚨Last chance to apply for the REMEDi4ALL Hackathon! Join an inspiring, hands-on event to tackle real-world drug repurposing challenges. 📍Montserrat, Barcelona | 6–10 October 2025 Only 1 week left to register – applications close 10 June. 🔗Apply now: loom.ly/2V3NnfI

Presented at ASCO this week, Dana-Farber researchers shared findings on whole-body MRI as a crucial test modality for individuals with Li-Fraumeni syndrome. The prospective cohort study found annual whole-body MRIs contribute substantially to detection of asymptomatic localized

We’re here! Really excited to hear about advances and opportunities at the CRUK Cancer Prevention Research Conference, which is being co-chaired by OCTO Director Sarah Blagden

Members of the MILI team are attending the 2025 CRUK Cancer Prevention Research Conference this week. #CRUK #LFS

The MILI site team based in Leicester Royal Infirmary speak on what this study means to them. Find out more about MILI here: mili.octru.ox.ac.uk #LFS #TP53 #LiFraumeniSyndrome Leicester's Hospitals

The #MILI trial is testing metformin for cancer prevention in people with #LiFraumeniSyndrome - if you have any questions we've got an extensive set of FAQs just added to our site: tp53.org.uk/mili-trial-faq…

🎓Since launch, the REMEDi4ALL Digital Academy has become a go-to resource for the drug repurposing community: 📘10 modules 🧠200+ topics 🌍170+ learners from 50+ countries 🔗 loom.ly/IeBJ9No

A MILI Milestone: 40 participants randomised onto the trial! Thank you to all our recruiting sites for your support of the trial. OUH, Guy's and St Thomas', Cambridge University Hospitals NHS, @nottmhospital, NHS Grampian, University Hospital Southampton 💙, Leicester's Hospitals #TP53 #LiFraumeniSyndrome #LFS