BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

We are looking for a new colleague!

How we present the project is the opposite of how we actually do the project

Very excited to share the structure and functional characterization of Clusterin, a key extracellular chaperone and apolipoprotein (ApoJ) linked to cancer, cardiovascular pathology and neurodegeneration. biorxiv.org/content/10.110…

Online Now: Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes dlvr.it/TGGX7c

Excited to report that we have discovered a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body. Specifically, in a new paper on BioRxiv, we show that RNA editing by the near-ubiquitous ADAR1 in

I’m thrilled to share this story from Joshua Mendell and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…

@nature, researchers report on their cryo-ET analysis of human TRiC/CCT -- the ATP-driven chaperonin the dysfunction of which is linked to disease. The work provides mechanistic insights into the functioning of this protein-folding machine within cells. shorturl.at/H69Ye

Now online! Structural determinants of co-translational protein complex assembly dlvr.it/THP30G

Now online! Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease dlvr.it/THPT97

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates: Cell cell.com/cell/fulltext/…

And here goes our brand new flyer #postdocjobs. Please RT!

We're recruiting a Research Assistant (new grant--details to follow!)--come help us work with primary human patient material to make cool 2D/3D co-culture systems, & learn more about how #proteostasis & #senescence play together in these contexts: babrahaminstitute.livevacancies.co.uk/#/job/details/…

Online Now: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation dlvr.it/TN0hJT

Early-career scientists: here’s your chance to lead independent research!🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! mpg.de/career/max-pla…👉

Our new nature study reveals a proteotoxic shock as a key mechanism of T-cell exhaustion. TexPSR (proteotoxic stress response in T-cell exhaustion) is driven by increased protein synthesis + buildup of misfolded proteins, leading to T-cell dysfunction. 👉 rdcu.be/eI3ch

My former PhD advisor got the Nobel Prize (John Clarke at Berkeley). It was without question the dullest work I’ve ever done in life and should have left earlier.

You can not do Bioinformatics with hard cutoffs and thresholds Let me tell you something real: Biology is more about p-values. It’s messier than that. 🧵

Nick Lane has a theory about the evolution of life which explains *why* life is the way that it is - all the contingent mechanisms you’re just supposed to take as givens in biology class. He thinks early life was continuous with the spontaneous chemistry of deepsea hydrothermal

Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset medrxiv.org/content/10.110…