Cancer cell therapies: global clinical trial trends and emerging directions nature.com/articles/d4157… This new article by authors Cancer Research Institute analyses trends across trial phases, indications, modalities, cell sources and targets to map the current trajectory of the field

Productive mRNA chromatin escape is promoted by PRMT5 activity dlvr.it/TP7R47

Summary of all the PD(L)1x VEGF bispecifics in development Uromigos #uromigoslive

A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence dlvr.it/TPB1Mt

UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance dlvr.it/TPB7J9

Recently posted in Small Molecule Therapeutics: PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo doi.org/10.1158/1535-7…

Our newly developed ChIP-CryoEM technique has, for the first time, visualized the moment when the UV-DDB protein recognizes and repairs UV-induced DNA damage within cells. nature.com/articles/s4146… #cryo #structure #biology

8 Resources to study Transcription factor binding, enhancers and histone modification distribution  1. ENCODE encodeproject.org

For readers interested in GLP-1-based therapies for diabetes, obesity and beyond, here's a recent review rdcu.be/ePXoK nature.com/articles/s4157…

A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases nature.com/articles/s4158…

YAP1 Depletion Enhances TAZ and its Complexation with TEAD4 and AP-1 Heterodimer C-JUN/FOSB to Promote Gastric Cancer Progression and ... biorxiv.org/content/10.110… #biorxiv_cancer

Online Now: MED1-driven ecDNA super-enhancers in cancer dlvr.it/TPKJMf

Online Now: Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module dlvr.it/TPL38W

Online Now: HSP90 buffers deleterious genetic variations in BRCA1 dlvr.it/TPM0bX

New Epigenome Technologies Blog post! bit.ly/47LGMay "Chromatin States in Pancreatic Ductal Adenocarcinoma Control Metastatic Spread" Based on a Nature Cancer paper from Kaloyan M. Tsanov and Scott W. Lowe #Epigenetics #Blog #EpigenomeTech #PDAC #Metastasis #Chromatin

Breaking the script: transcriptional addiction as a driver of genome instability in cancer dlvr.it/TPMPtz

In classical PDAC, tumour drivers change with the disease state: 🔹 Primary tumors rely on HNF4G 🔹 Metastasis emerges as FOXA1 becomes derepressed Our new research briefing in Nature Genetics breaks down this transcriptional shift and its implications- nature.com/articles/s4158…

Now online in Cancer Discovery: DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency - by Thomas Köhnke, Daiki Karigane Majeti Lab and colleagues doi.org/10.1158/2159-8… Stanford Medicine

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA) | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Nature research paper: NSD2 targeting reverses plasticity and drug resistance in prostate cancer go.nature.com/48oN7Id