If you're interested in Synbio, this is a great reading list to start off. There's a lot of material here, take it slowly. You're not late. And there's room for everyone. The Codon Guide to Synthetic Biology, by Niko McCarty 🧫 readcodon.com/p/synbio-guide…

A few comments regarding #zone2 training: When I started the Zone 2 concept ~30 years ago, it was successful with elite athletes but back in the days, nobody talked about fitness, longevity, mitochondrial function or metabolic health. Back then it was more about improving

A team of researchers at the University of Rochester has achieved a remarkable feat - the successful transfer of a longevity gene from the naked mole rat to mice, resulting in improved health and an extension of the mouse’s lifespan. synbiobeta.com/read/from-rats…

The company landscape for artificial intelligence in large-molecule drug discovery bit.ly/3Ej2ymC A new analysis highlighting how AI-based approaches are being applied in large-molecule drug discovery, the companies developing these approaches and their pipelines

With CRISPR-Cas9, a repressor of fetal hemoglobin expression was disrupted in hematopoietic stem cells from three persons with sickle cell disease. Edited cells were reinfused. Hematopoiesis was restored. Read the full study results: nej.md/3L64brp

Demand for weight-loss drugs Ozempic/Wegovy is so large that the government of Denmark (where drugmaker Novo Nordisk is from) now has to publish GDP data excluding it Since the first half of 2022 (left), headline GDP growth has been 1.7% (blue), but ex-Pharma it's -0.3% (green)

Another day, another Cas12a paper 😁 A tour…. Optimization of Cas12a for multiplexed genome-scale transcriptional activation: Cell Genomics cell.com/cell-genomics/…

No technology has ever improved more rapidly than DNA sequencing. The resulting explosion of genomic data has played a central role in transforming biology into an information science. We now browse genomes, search vast databases of biological annotations, and explore digital

For bio phds/postdocs interested in taking the venture capital/investor route. This is an exciting space with a lot of potential for impact. I highly recommend following these brilliant people to learn more 👇 Dr. Shelby Jay Rughani Amee Kapadia Patrick Malone, MD PhD Pablo Lubroth

Pretty wild to me that my story is on the front page of Massachusetts Institute of Technology (MIT) right now. news.mit.edu/2023/scientist…

Everyone on Nobel Day: "See you don't need a CNS paper to succeed in science!" Everyone every other day: "If I don't get a CNS paper I'll never succeed in science."

Nature rejected her paper for not being original, University of Pennsylvania (her employer) demoted her, and yesterday Katalin Karikó won the Noble Prize in physiology. In mid-2000s, Karikó and her Drew Weismann submitted their paper on mRNA (messenger Ribonucleic Acid) to

You can outperform most venture funds by buying LEGO. I analyzed the last 20 years of secondhand LEGO pricing data, and found randomly purchasing sets will match most VC's returns if you're somewhat intentional about what you buy-- you massively outperform even the best firms

New from my lab: we show that a clinical-stage oncology drug from Eli Lilly is mischaracterized, and its true anti-cancer target is EGFR. We also show how in vitro drug assays can be misleading - cellular+genetic methods are needed to determine drug MOAs.

Very excited to announce the publication of our Nature Paper. Please read below! Thank you to all who contributed.

Happy that our review is out! We go over different methods to make and modify hydrogel biomaterials geared towards various application spaces. We also provide a deep dive into (bio)chemical platforms that show the most translational promise. Hope it proves a useful read!

The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity businesswire.com/news/home/2023…

Our latest paper entitled "One-Step Purification and N-Terminal Functionalization of Bioactive Proteins via Atypically Split Inteins" (#VEPL) is now live at Bioconjugate Chem! doi.org/10.1021/acs.bi… Huge congrats to RyanGharios, publishing it just days before his UW Chemical Engineering defense!

Congrats to DOCTOR RyanGharios on successfully defending his PhD as part of UW Chemical Engineering! On to bigger and better things... but, first, champagne! 🍾 Here's his just-published paper on N-terminal protein modification (#VEPL): doi.org/10.1021/acs.bi… Stay tuned for more! 🎉