"The Peptide Vaccine of the Future" Nelde et al. of Universität Tübingen discuss current approaches in the development of peptide-based vaccines and critical implications for optimal #vaccine design ― Annika Nel Peptide-based Immunotherapy #Immunopeptidomics #Immunology #TeamMassSpec mcponline.org/article/S1535-…

Antigen presentation by MHC-2 is not simply a matter of binding affinity. In this collaborative work with Betsy Mellins, we show that large portions of MHC-2 repertoires are sensitive to the variable activity of the antigen loading Dm chaperone and it’s antagonist, Do

A small fraction of researchers in KATY #WorldCancerDay Alexander Laird RVCrypto Yamir Moreno Christophe Battail Catia Pesquita Francisco Lupiáñez-Villanueva Laurent Guyon Javier Alfaro @kbarud Georges BEDRAN Aria Nourbakhsh Michele Mastromattei

FIU algorithm harnesses power of supercomputers | FIU News - Florida International University disq.us/t/44x9o33

Thrilled to share our Pan-Cancer Proteomic Map of 949 Human Cancer Cell Lines, now on bioRxiv. A huge collaboration between CMRI #ProCan and Garnett Lab Wellcome Sanger Institute Cancer Dependency Map Sanger. Thanks to @emanuelvgo, Simon Cai and the whole team. biorxiv.org/content/10.110…

Any Occupational Therapists with experience in working with dementia patients? I'm searching for OT's to join our discussion panel on the Early Prevention of Neurodegenerative Diseases during online Applied Neurosciences Association conference on 23rs of March. #dementia

I’m delighted to share our Nature Cancer paper by Anne Kraemer et al. nature.com/articles/s4301… Our objective was to investigate whether there are substantial differences in the antigenic landscape presented in tumors that are T cell inflamed versus those that are non-inflamed.

Don’t miss out on this promising source of tumor antigens! #vaccins #Cancer

This TCR:pMHC discovery platform is pretty cool (TCR activation -> scFv release which labels the relevant APC) biorxiv.org/content/10.110… What I really love though is them finding/making better TCR signaling reporter promoters than vanilla NFAT, definitely going to try them out

This is what you all sound like when hyping up AI

Georges BEDRAN, Dan Polasky from Alexey Nesvizhskii and colleagues present a computational workflow for identifying glycosylated peptides from mass spectrometry-based immunopeptidome data and investigate the properties of glycosylated MHC associated peptides nature.com/articles/s4146…

An atlas of non-canonical MHC class I–associated peptides is created and provides potential targets for #Tcell therapies or vaccines— In this study by Georges BEDRAN, Sachin Kote, Javier Alfaro et al. bit.ly/3PiCEWG Dominika Bedran Neuroscientist Fabio Massimo Zanzotto Aleksander Pałkowski goodlettlab

PTM-containing peptides often fragment in unexpected ways, hindering their identification. Here we describe a workflow in #FragPipe to find diagnostic spectral features for any PTM, illustrated using chemoproteomics, RNA-xlinks, glyco and ADP-ribo examples nature.com/articles/s4146…

Led by Fengchao Yu we present MSFragger-DIA for direct peptide identification from DIA data. It leverages the speed of fragment ion indexing and searches DIA MS/MS spectra prior to feature detection and peak tracing. Complete DIA analysis workflow in #FragPipe nature.com/articles/s4146…

MSBooster manuscript led by Kevin Yang is out! In tandem with Percolator, it improves identification rates in #FragPipe using deep learning-based predictions (from DIA-NN). We illustrate it using HLA peptidomics, direct DIA, single-cell, and timsTOF data. nature.com/articles/s4146…