Check out our new study with @morehouse_ben and the Kranzusch lab looking at how a cognate second messenger induces oligomerization and activation of bacterial STING - fun EM images by Matthew Yip and Alex! nature.com/articles/s4158…

One of the coolest mechanisms we’ve worked on: rdcu.be/cSPbR Matthew Yip and @samanthasedor reveal how the hybrid E2/E3 enzyme UBE2O, which ubiquitinates unassembled ribosomal proteins for degradation, selects its clients.

Less than two weeks until the deadline (Oct. 12) to submit an application for the open @HarvardCellBio junior faculty search!

It’s intuitive that cells will fix aberrant proteins (if possible) before trashing them, but examples remain limited. Our new study by Michael McKenna describes how corrective protein quality control by the P5A-ATPase ATP13A1 prevents wasteful ERAD. authors.elsevier.com/a/1fzWJ_Oylrkq…

So excited to see my thesis work out in the wild! Here we show that the Integrator complex can terminate early transcription at all RNA Pol 2 (RNAPII)-transcribed loci. A brief thread with highlights: (1/8) authors.elsevier.com/c/1f~w43vVUPK9…

Finally out! Check our new resource of neuropeptide-GPCR interactions in C. elegans. We identify 461 peptide-GPCR pairs that allow mapping peptidergic circuits. See also this application on the worm's peptide connectome doi.org/10.1101/2022.1… Resource: doi.org/10.1101/2022.1… 🧵

Check out the latest paper from the Balasubramanian group with the amazing first author Silvia Galli, where we describe the development of a nanobody to detect and map G-quadruplexes in cells Larry Melidis Siskin @sflynn4 🥳🥳

An update of our latest work on how animals learn behavioral sequences: The behavioral signature of stepwise learning strategy and its neural correlate in the basal forebrain biorxiv.org/content/10.110…

The latest installment of Luke Coddington studies on how dopamine (DA) shapes learning rdcu.be/c3Ibf This was a tricky one; it combines a few ideas that together argue for a new way to understand DA function and account for data that evaded prior models. 1/n

Brilliant Markus Höpfler presents you the mechanism of autoregulated tubulin mRNA death! The pleasure of having contributed to this story is unmeasurable. Read more about this elegant pathway, and how important it is for a healthy cell division and a healthy human! 👇

So excited to see my postdoc work out in the world! Here we show that EP400/TIP60 can broadly compensate for loss of SWI/SNF activity at promoters. See below for a short(ish) thread on our work (1/X): biorxiv.org/content/10.110…

Here is a story of how Jinkuk Kim found an antisense oligonucleotide (ASO) that can up-regulate a key protein in a neurodegenerative disease. Joint work between my lab and Tim Yu. 1/n tinyurl.com/ycka3yha

So excited to share that my thesis work is out now at Molecular Cell! Karen AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY3vVUPNx…

I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors Dr. Helena Zomer Geoff Nelson AdelmanLab, Irene, Debarun, and Prabu!!

Really excited to share the latest work on #BasalForebrain from our lab: "The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain" buff.ly/44Zmt5j just published in Nature Communications (1/n)

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

Happy to announce the final version of our paper is now available Nature Communications! nature.com/articles/s4146… Thank you to co-authors Kavya, Geoff Nelson Dr. Helena Zomer, Debarun, Irene, Reza, Huanyu, AdelmanLab and Prabu for a great collaboration of transcription and development expertise!

Delighted to share our latest research published in nature. Honored to have been part of this fantastic work led by Sandi-Radko-Juettner and Hong Yue. Congratulations to all the authors!!!

I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to BlacklowLab and AdelmanLab and all co-authors! biorxiv.org/content/10.110…