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🚀 Just published on bioRxiv! 🔍DiffInvex evolutionary model for conditional somatic selection✅ 🧬A genomic study of 10,000 cancer whole genomes identifying chemoresistant genes (putative therapeutic targets)✅ 👨‍💻DiffInvex soon on GitHub⌛️ 📄: biorxiv.org/content/10.110… (1/7) ⬇️

Very excited to have my first preprint published! 🥳 Thanks to Fran Supek and our lab Genome Data Science lab 🧬

A much improved version of this, today out in Nature Genetics ! with Ben Lehner and Fran Supek nature.com/articles/s4158…

2. Early stop codons cause ~10–20% of genetic conditions A promising approach is to force the ribosome to ignore the stop codon, using a drug, to produce full-length proteins How effective this is depends on the drug, the gene, and the stop codon nature.com/articles/s4158…

🔢💊Un algoritmo desarrollado por expertos del #IRBBarcelona y del Centre for Genomic Regulation (CRG) puede predecir qué fármacos serán más efectivos para el tratamiento de enfermedades genéticas y del #cáncer. 📰EFE Comunicación ➡️shorturl.at/7nmVO Genome Data Science lab Ben Lehner Ignasi Toledano

🤖The Genome Data Science lab develops #ArtificialIntelligence (#AI) models to predict epigenetic disturbances that result from inherited mutations. Their aim is to better predict how heritable and epigenetic changes jointly shape the risk of developing #LungCancer in every individual.

New pre-print out! 👨‍🔬 🔗biorxiv.org/content/10.110… Here, we studied the incidence and impact of allele-specific expression (ASE; imbalance between two alleles in mRNA levels ⚖️) in tumorigenesis. 1/6

EMBO DNA Replication symposium -> still in time to register to attend! 👏to our Veiner Marcell and Marina Salvadores Ferreiro - they will have talks on using 🤖#AI and cancer mutation analysis to understand 🧬DNA replication in human cells👇 embl.org/about/info/cou…

No less than 6⃣6⃣ PhD fellowships will be available to assorted groups at 🌆U of Copenhagen & to 🇩🇰DTU via the "INTERACT" call 🎓Applications open 20/12. Spread the word! Apply + join us👇 Maybe there is a Nobel prize in physics awaiting you as well 😁 linkedin.com/posts/biotech-…

🔥PhD student & postdoc opportunity Genome Data Science lab! Are you keen on: - driving cutting-edge science @ interface of #AI and cancer #genomics? - working in a dynamic & supportive environment of @UCPH_BRIC? - joining the U of Copenhagen, top-3 ranked uni in EU? Apply below👇

The youngsters from lab are at EMBL Events DNA Replication symposium #EESreplication 🧬 Our alumna dr. Marina Marina Salvadores Ferreiro and PhD Marcell Veiner Marcell gave talks on their recent work 👏-- identifying DNA replication origins by mutation patterns and neural nets🤖

Postdoc and PhD position in AI for cancer genomics at BRIC/UCPH. Only 5 days left to apply!

Website for the Marie Curie "INTERACT" call for interdisciplinary PhD fellowships at UCph/DTU/DCS is now up 👇 interact-msca.ku.dk Applications open 20th December.

Double PhD defense day in the lab 🤩 Congrats to our dr. Guille Palou Guillermo Palou Márquez, fresh from the oven 🎊🥳 and similarly so our newly-minted dr. Ignasi Toledano Ignasi Toledano! Amazing defense both, bravo 👏👏

Great news – we received funding from the Independent Research Fund Denmark DK Frie Forsk.fond! 🧬We will study #cancer driver mutations in tumor suppressor genes. In particular, we will focus on so-called "dominant negative" mutations, by combining #genomics, #AI & CRISPR gene editing

🚨 Big news! I'm thrilled to share that our latest research has just been published in Nature Communications 🎉 🔍 Title: DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy 📎 doi.org/10.1038/s41467… (1/4) ⬇️

🧵Ahmed’s Genome Data Science lab paper on evolution of chemotherapy resistance is out in Nature Communications! We developed DiffInvex - a method tracking how #cancer driver genes change under therapy, applied to ~10k genomes. Key insight: resistance often emerges through existing pathways. 1/5