Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS cell.com/neuron/fulltex…

1/ One of the most common mistakes in bioinformatics is the one-off error. If you are not careful, you will make mistakes. Even experienced bioinformaticians are not aware of it and the mistake prevails in many bioinformatics tools. A thread 🧵

Finally out!!! CRISPR/dCasRx as a versatile tool to not only edit RNA splicing BUT ALSO to identify new regulatory RNA elements. Read more at Nucleic Acids Res, Institut Curie, CRISPR News 🧬 doi.org/10.1093/nar/gk…

In the latest issue! Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas dlvr.it/TCR1Rl

Excited to share our latest work on how the RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites! biorxiv.org/content/10.110…

Analyses of neuroimaging datasets from 5306 participants across 15 countries found generally larger brain-age gap in Latin-American compared to non-Latin American populations, which were influenced by disparities in socioeconomic and health-related factors nature.com/articles/s4159…

Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome Nature Genetics Yang I Li nature.com/articles/s4158…

Our paper ‘Whole-embryo Spatial Transcriptomics at Subcellular Resolution from Gastrulation to Organogenesis’ is now on biorxiv! We introduce weMERFISH, a platform for profiling gene expression in entire embryos at subcellular resolution. Here is🧵biorxiv.org/content/10.110… (1/12)

The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI. I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm. You can find the first lecture here: youtu.be/1zZSPeKGRzw and more will

DeepKINET: a deep generative model for estimating single-cell RNA splicing and degradation rates genomebiology.biomedcentral.com/articles/10.11…

Another splicesomal RNA implicated in recurrent mutations leading to neurodevelopmental disorders, and yet again based on the whole genome sequencing of patients Genomics England who consented for responsible on going research to help understand their (or their child's) disease

chatomics! Gene Set Enrichment Analysis using RNA Sequencing Data youtube.com/watch?v=IKCDQE… #rstats #bioinformatics

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Loss of a specific RNA-binding protein leads to the accumulation of RNAs in neurites, disrupting motor protein activity. Joelle Lo, Matthew Taliaferro and team explore the role of HNRNPA2B1 in neurons. Check out the first #preLight of Felipe Del Valle below ⬇️ 👀 prelights.biologists.com/highlights/the…

🧵 1/9 Delighted to announce that #DeepRVAT is out today in Nature Genetics! Here's a recap of our tweetorial from the preprint, with updates for some exciting new results. It's been a joy to work with Eva Holtkamp, as well as gagneurlab and Oliver Stegle.

Part 1 of our venture into the world of alternative translation-linked proteoforms! (Now Dr) Paul Lee, Yu Sun, along w/Alexa Soares and others in Marina Picciotto lab found that alternative TIS pairs change the localization and functions of synaptic organizers! authors.elsevier.com/a/1jpc73vVUPRm…

CREATE: cell-type-specific cis-regulatory elements identification via discrete embedding biorxiv.org/content/10.110…

If you are about RNA-seq and alternative splicing and wondering whether to spend more money on long reads, this paper is extremely important. Longer is not always better. Long read experiment with a LOT of reads missed some splicing events. genome.cshlp.org/content/early/…

mulea: An R package for enrichment analysis using multiple ontologies and empirical false discovery rate bmcbioinformatics.biomedcentral.com/articles/10.11…

Although computers cannot think, they can mimic functions such as memory and learning. This year’s physics laureates helped make this possible. Learn more about their work: nobelprize.org/prizes/physics… #NobelPrize